biostudies-literatureUnknown12(4)Lerner AMichael J. Fox Foundation for Parkinson's ResearchMichael J. Fox Foundation for Parkinson&apos;s Research<h4>Background</h4>Limited evidence exists regarding the meaningfulness of symptoms experienced in early Parkinson's disease (PD).<h4>Objectives</h4>To identify the most bothersome symptoms experienced by people with early PD, leveraging data from the Parkinson's Disease Patient Report of Problems (PD-PROP) questionnaire within the Fox Insight Study.<h4>Methods</h4>Individuals with a self-reported diagnosis of PD completed the PD-PROP questionnaire, reporting up to five most bothersome symptoms. Symptom types and frequencies were derived through a combination of human expertise and machine learning.<h4>Results</h4>Participants (N = 8536) were 0.9 years since diagnosis, predominantly white (96%), male (53.3%), and with an average age of 64.6 years. Top most bothersome motor symptoms were trMovement disorders clinical practice510-515https://www.ebi.ac.uk/biostudies/studies/S-EPMC11998684biostudies-literatureFox Insight: Most Bothersome Symptoms in Early-Stage Parkinson's Disease.PMC11998684Auinger PAl-Rubayie RLerner AXiao YAdams JLMarras CMammen JRTyo MfalseFox Insight: Most Bothersome Symptoms in Early-Stage Parkinson's Disease.<h4>Background</h4>Limited evidence exists regarding the meaningfulness of symptoms experienced in early Parkinson's disease (PD).<h4>Objectives</h4>To identify the most bothersome symptoms experienced by people with early PD, leveraging data from the Parkinson's Disease Patient Report of Problems (PD-PROP) questionnaire within the Fox Insight Study.<h4>Methods</h4>Individuals with a self-reported diagnosis of PD completed the PD-PROP questionnaire, reporting up to five most bothersome symptoms. Symptom types and frequencies were derived through a combination of human expertise and machine learning.<h4>Results</h4>Participants (N = 8536) were 0.9 years since diagnosis, predominantly white (96%), male (53.3%), and with an average age of 64.6 years. Top most bothersome motor symptoms were tr2025-01-01T00:00:00Z2025 Apr2025-07-03T03:06:12.771Z2025-07-03T03:06:12.771ZS-EPMC119986843975438610.1002/mdc3.14321