biostudies-literatureBianchi EEuropean Synchrotron Radiation FacilityMinistero dell'Istruzione dell'Università e della RicercaInstituto Nazionale di Fisica NucleareUniversità degli Studi di PaviaEuropean Commission101699https://www.ebi.ac.uk/biostudies/studies/S-EPMC11999374biostudies-literatureUnknown32Nowadays, tendon injuries represent a global health issue that annually affects millions of individuals. An innovative approach for their treatment is represented by the development of tissue engineered scaffolds able to support the host cells adhesion, differentiation, and proliferation. However, the scaffold alone could be insufficient to guarantee an improvement of healing control. Magnetite nanoparticles (Fe₃O₄ NPs) are gaining interest due to their unique properties. In particular, when combined with bio-mimetic scaffolds, they should lead to the cells mechano-stimulation, improving the tenogenic differentiation and allowing a deeper tissue reparation. The aim of this work is the study and the development of scaffolds based on polyhydroxybutyrate and gelatin and Materials today. BioMagnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration.PMC11999374MD-1406 2023ECS00000036Bianchi EZanovello JCasettari LDel Favero EAlbino MVigani BSandri GRossi SIcaro Cornaglia ALascialfari AJannelli EPavesi FCBanobre-Lopez MSangregorio CRuggeri MRicci CBoselli CfalseMagnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration.Nowadays, tendon injuries represent a global health issue that annually affects millions of individuals. An innovative approach for their treatment is represented by the development of tissue engineered scaffolds able to support the host cells adhesion, differentiation, and proliferation. However, the scaffold alone could be insufficient to guarantee an improvement of healing control. Magnetite nanoparticles (Fe₃O₄ NPs) are gaining interest due to their unique properties. In particular, when combined with bio-mimetic scaffolds, they should lead to the cells mechano-stimulation, improving the tenogenic differentiation and allowing a deeper tissue reparation. The aim of this work is the study and the development of scaffolds based on polyhydroxybutyrate and gelatin and 2025-01-01T00:00:00Z2025 Jun2026-06-01T13:05:14.809Z2025-07-14T03:02:47.461ZS-EPMC119993744023681510.1016/j.mtbio.2025.101699