{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su F"],"funding":["Shandong Province Natural Science Foundation","National Natural Science Foundation of China","Taishan Scholar Foundation of Shandong Province"],"pagination":["1383-1393"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11999485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27"],"pubmed_abstract":["The sea cucumber <i>Apostichopus japonicus</i>, renowned for its remarkable ability to expel and regenerate its internal organs within weeks, serves as a model organism for regeneration research. However, studies on the role of non-coding RNAs, particularly long non-coding RNA (lncRNA), in intestinal regeneration remain limited. In this study, we identified and performed differential expression analysis of lncRNAs in both normal intestines and intestines at 3 days post evisceration (dpe). A total of 2361 lncRNAs were identified, 183 of which were differentially expressed (DE-lncRNAs). The genes targeted by these lncRNAs, either cis- or trans-acting, were involved in oxidative stress, immune response, extracellular matrix remodeling, and energy metabolism during intestinal regeneration. Notably, MSTRG.6200/miR-7847-3p and MSTRG.18440/miR-4220-5p have been confirmed as interacting lncRNA-miRNA pairs. These results suggest that lncRNAs are key regulators of intestinal regeneration in <i>A. japonicus</i>, offering new insights into the underlying mechanisms and potential targets for enhancing regeneration."],"journal":["Computational and structural biotechnology journal"],"pubmed_title":["LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumber &lt;i&gt;Apostichopus japonicus&lt;/i&gt;."],"pmcid":["PMC11999485"],"funding_grant_id":["42076093","ZR2024YQ050","42106131","42276143","202306279"],"pubmed_authors":["Yang H","Sun L","Wang T","Zhang L","Dolmatov IY","Ding K","Su F"],"additional_accession":[]},"is_claimable":false,"name":"LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumber &lt;i&gt;Apostichopus japonicus&lt;/i&gt;.","description":"The sea cucumber <i>Apostichopus japonicus</i>, renowned for its remarkable ability to expel and regenerate its internal organs within weeks, serves as a model organism for regeneration research. However, studies on the role of non-coding RNAs, particularly long non-coding RNA (lncRNA), in intestinal regeneration remain limited. In this study, we identified and performed differential expression analysis of lncRNAs in both normal intestines and intestines at 3 days post evisceration (dpe). A total of 2361 lncRNAs were identified, 183 of which were differentially expressed (DE-lncRNAs). The genes targeted by these lncRNAs, either cis- or trans-acting, were involved in oxidative stress, immune response, extracellular matrix remodeling, and energy metabolism during intestinal regeneration. Notably, MSTRG.6200/miR-7847-3p and MSTRG.18440/miR-4220-5p have been confirmed as interacting lncRNA-miRNA pairs. These results suggest that lncRNAs are key regulators of intestinal regeneration in <i>A. japonicus</i>, offering new insights into the underlying mechanisms and potential targets for enhancing regeneration.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-08T19:18:17.261Z","creation":"2025-07-14T03:02:52.775Z"},"accession":"S-EPMC11999485","cross_references":{"pubmed":["40235637"],"doi":["10.1016/j.csbj.2025.03.047"]}}