{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39"],"submitter":["Di Gennaro F"],"pubmed_abstract":["<h4>Background</h4>Identifying accessible and reliable biomarkers for tuberculosis (TB) severity is crucial for improving patient management. This study evaluates hematological findings as potential indicators of TB severity in a large multicenter Italian cohort.<h4>Methods</h4>This retrospective, multicenter, cross-sectional study analyzed hematological parameters (hemoglobin, white blood cells, inflammatory indices, hepatorenal function, albuminuria) in 577 TB patients from 10 Italian centers (2018-2023). Severe TB was defined by at least two criteria: TIMIKA score > 60, sputum conversion time > 21 days, or need for oxygen supplementation. Statistical analyses included receiver operating characteristic curve (AUC) evaluation, calibration curves, and clinical utility.<h4>Results</h4>Of th"],"journal":["Journal of clinical tuberculosis and other mycobacterial diseases"],"pagination":["100517"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11999573"],"repository":["biostudies-literature"],"pubmed_title":["Hematochemical hallmarks as markers of pulmonary TB severity: A multicenter cross-sectional study."],"pmcid":["PMC11999573"],"pubmed_authors":["Monari C","Fasano M","Papagni R","Minniti S","Ieva FRP","Gualano G","De Iaco G","Cotugno S","Lattanzio R","De Vita E","Saracino A","Pontarelli A","Pipito L","Ronga L","Pisaturo M","Palmieri F","Iacovazzi T","De Gregorio F","Cascio A","Panico G","Di Bari V","Alessio L","Di Gennaro F","Zimmerhofer F","Santoro CR","Libertone R","Niglio M","Bruno G","Carbonara S","Cavallin F","Botta A","Brindicci G","Onorato L","Buccoliero GB","Lo Caputo S","Parrella R","Coppola N","Guido G","Musto A"],"additional_accession":[]},"is_claimable":false,"name":"Hematochemical hallmarks as markers of pulmonary TB severity: A multicenter cross-sectional study.","description":"<h4>Background</h4>Identifying accessible and reliable biomarkers for tuberculosis (TB) severity is crucial for improving patient management. This study evaluates hematological findings as potential indicators of TB severity in a large multicenter Italian cohort.<h4>Methods</h4>This retrospective, multicenter, cross-sectional study analyzed hematological parameters (hemoglobin, white blood cells, inflammatory indices, hepatorenal function, albuminuria) in 577 TB patients from 10 Italian centers (2018-2023). Severe TB was defined by at least two criteria: TIMIKA score > 60, sputum conversion time > 21 days, or need for oxygen supplementation. Statistical analyses included receiver operating characteristic curve (AUC) evaluation, calibration curves, and clinical utility.<h4>Results</h4>Of th","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2025-07-14T03:02:50.898Z","creation":"2025-07-14T03:02:50.898Z"},"accession":"S-EPMC11999573","cross_references":{"pubmed":["40235620"],"doi":["10.1016/j.jctube.2025.100517"]}}