biostudies-literatureUnknown39Di Gennaro F<h4>Background</h4>Identifying accessible and reliable biomarkers for tuberculosis (TB) severity is crucial for improving patient management. This study evaluates hematological findings as potential indicators of TB severity in a large multicenter Italian cohort.<h4>Methods</h4>This retrospective, multicenter, cross-sectional study analyzed hematological parameters (hemoglobin, white blood cells, inflammatory indices, hepatorenal function, albuminuria) in 577 TB patients from 10 Italian centers (2018-2023). Severe TB was defined by at least two criteria: TIMIKA score > 60, sputum conversion time > 21 days, or need for oxygen supplementation. Statistical analyses included receiver operating characteristic curve (AUC) evaluation, calibration curves, and clinical utility.<h4>Results</h4>Of thJournal of clinical tuberculosis and other mycobacterial diseases100517https://www.ebi.ac.uk/biostudies/studies/S-EPMC11999573biostudies-literatureHematochemical hallmarks as markers of pulmonary TB severity: A multicenter cross-sectional study.PMC11999573Monari CFasano MPapagni RMinniti SIeva FRPGualano GDe Iaco GCotugno SLattanzio RDe Vita ESaracino APontarelli APipito LRonga LPisaturo MPalmieri FIacovazzi TDe Gregorio FCascio APanico GDi Bari VAlessio LDi Gennaro FZimmerhofer FSantoro CRLibertone RNiglio MBruno GCarbonara SCavallin FBotta ABrindicci GOnorato LBuccoliero GBLo Caputo SParrella RCoppola NGuido GMusto AfalseHematochemical hallmarks as markers of pulmonary TB severity: A multicenter cross-sectional study.<h4>Background</h4>Identifying accessible and reliable biomarkers for tuberculosis (TB) severity is crucial for improving patient management. This study evaluates hematological findings as potential indicators of TB severity in a large multicenter Italian cohort.<h4>Methods</h4>This retrospective, multicenter, cross-sectional study analyzed hematological parameters (hemoglobin, white blood cells, inflammatory indices, hepatorenal function, albuminuria) in 577 TB patients from 10 Italian centers (2018-2023). Severe TB was defined by at least two criteria: TIMIKA score > 60, sputum conversion time > 21 days, or need for oxygen supplementation. Statistical analyses included receiver operating characteristic curve (AUC) evaluation, calibration curves, and clinical utility.<h4>Results</h4>Of th2025-01-01T00:00:00Z2025 May2025-07-14T03:02:50.898Z2025-07-14T03:02:50.898ZS-EPMC119995734023562010.1016/j.jctube.2025.100517