{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["68(2)"],"submitter":["Borges FK"],"pubmed_abstract":["<h4>Background</h4>Timing to surgery for acute cholecystitis remains variable, ranging from early (< 7 d) to delayed surgery (> 7 d). Accelerated surgery may result in better outcomes owing to reduced exposure to hypercoagulable and inflammatory states. We sought to determine the feasibility of a trial comparing accelerated surgery with standard care among patients with calculous acute cholecystitis.<h4>Methods</h4>We conducted a multicentre pilot randomized controlled trial. We randomly assigned adult patients with acute cholecystitis to receive accelerated surgery (i.e., goal of surgery within 6 hours of diagnosis) or standard care. The primary feasibility outcome included recruitment of 60 patients, randomly assigning the equivalent of 1 patient per site per month, and 95% follow-up at 90 days.<h4>Results</h4>Sixty patients (mean age 61.7, standard deviation [SD] 13.5, yr; 27 [45%] female) were randomly assigned to accelerated surgery (<i>n</i> = 31) or standard care (<i>n</i> = 29) from December 2019 to December 2021, with 2 recruitment pauses due to the COVID-19 pandemic. The median time from diagnosis to surgery was 5.8 (interquartile range [IQR] 4.4-11.1) hours in the accelerated care arm and 20.3 (IQR 6.8-26.8) hours in the standard care arm. Across 4 sites, 4.6 patients per month were randomly assigned. All patients completed the 90-day follow up.<h4>Conclusion</h4>In our pilot trial, we found that accelerated cholecystectomy was achievable. These results show the feasibility of a trial comparing accelerated and standard care among patients requiring surgery for acute cholecystitis and support a definitive trial.<h4>Trial registration</h4>ClinicalTrials.gov, no. NCT04033822."],"journal":["Canadian journal of surgery. Journal canadien de chirurgie"],"pagination":["E122-E131"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11999720"],"repository":["biostudies-literature"],"pubmed_title":["Fast Track Pathway to Accelerated Cholecystectomy Versus Standard of Care for Acute Cholecystitis (FAST) pilot trial."],"pmcid":["PMC11999720"],"pubmed_authors":["Borges FK","Di Sante E","Nenshi R","Park LJ","Devereaux PJ","Vincent J","Tsiplova K","Serrano PE","Vogt K","Engels P"],"additional_accession":[]},"is_claimable":false,"name":"Fast Track Pathway to Accelerated Cholecystectomy Versus Standard of Care for Acute Cholecystitis (FAST) pilot trial.","description":"<h4>Background</h4>Timing to surgery for acute cholecystitis remains variable, ranging from early (< 7 d) to delayed surgery (> 7 d). Accelerated surgery may result in better outcomes owing to reduced exposure to hypercoagulable and inflammatory states. We sought to determine the feasibility of a trial comparing accelerated surgery with standard care among patients with calculous acute cholecystitis.<h4>Methods</h4>We conducted a multicentre pilot randomized controlled trial. We randomly assigned adult patients with acute cholecystitis to receive accelerated surgery (i.e., goal of surgery within 6 hours of diagnosis) or standard care. The primary feasibility outcome included recruitment of 60 patients, randomly assigning the equivalent of 1 patient per site per month, and 95% follow-up at 90 days.<h4>Results</h4>Sixty patients (mean age 61.7, standard deviation [SD] 13.5, yr; 27 [45%] female) were randomly assigned to accelerated surgery (<i>n</i> = 31) or standard care (<i>n</i> = 29) from December 2019 to December 2021, with 2 recruitment pauses due to the COVID-19 pandemic. The median time from diagnosis to surgery was 5.8 (interquartile range [IQR] 4.4-11.1) hours in the accelerated care arm and 20.3 (IQR 6.8-26.8) hours in the standard care arm. Across 4 sites, 4.6 patients per month were randomly assigned. All patients completed the 90-day follow up.<h4>Conclusion</h4>In our pilot trial, we found that accelerated cholecystectomy was achievable. These results show the feasibility of a trial comparing accelerated and standard care among patients requiring surgery for acute cholecystitis and support a definitive trial.<h4>Trial registration</h4>ClinicalTrials.gov, no. NCT04033822.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar-Apr","modification":"2026-06-01T17:56:36.809Z","creation":"2025-06-26T03:06:08.556Z"},"accession":"S-EPMC11999720","cross_references":{"pubmed":["40216437"],"doi":["10.1503/cjs.016423"]}}