{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["49(4)"],"submitter":["Lambert C"],"pubmed_abstract":["<h4>Background</h4>This study aims to investigate the differential miRNA expression profile between the visceral white adipose tissue and the skeletal muscle of people with obesity undergoing bariatric surgery.<h4>Methods</h4>Skeletal muscle and visceral adipose tissue samples of 10 controls and 38 people with obesity (50% also with type 2 diabetes) undergoing bariatric surgery were collected. miRNA expression profiles were analyzed using Next-Generation Sequencing and subsequently validated using RT-PCR.<h4>Results</h4>Approximately 69% of miRNAs showed similar expression in both tissues, however, 55 miRNAs were preferentially expressed in visceral adipose tissue and 53 in skeletal muscle. miR-122b-5p was uniquely identified in skeletal muscle, while miR-1-3p and miR-206 were upregulated in skeletal muscle. Conversely, miR-224-5p and miR-335-3p exhibited upregulation in visceral adipose tissue. Notably, distinctions related to the presence of type 2 diabetes were observed solely in the expression of miR-1-3p and miR-206 in visceral adipose tissue.<h4>Conclusions</h4>This is the first study unveiling distinct miRNA expression profiles in paired samples of visceral adipose tissue and skeletal muscle in humans. The identification of obesity-specific miRNAs in these tissues opens up promising avenues for research into potential biomarkers for obesity diagnosis and treatment."],"journal":["International journal of obesity (2005)"],"pagination":["634-641"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11999863"],"repository":["biostudies-literature"],"pubmed_title":["Exploring differential miRNA expression profiles in muscular and visceral adipose tissue of patients with severe obesity."],"pmcid":["PMC11999863"],"pubmed_authors":["Sanz Alvarez LM","Garcia-Villarino M","Latorre J","Garcia AV","Uria RR","Morales-Sanchez P","Moreno Gijon M","Lambert C","Ares-Blanco J","Menendez-Torre E","Villa-Fernandez E","Fernandez-Real JM","Navarro SS","Pujante P","Suarez-Gutierrez L","Delgado E","Turienzo Santos EO"],"additional_accession":[]},"is_claimable":false,"name":"Exploring differential miRNA expression profiles in muscular and visceral adipose tissue of patients with severe obesity.","description":"<h4>Background</h4>This study aims to investigate the differential miRNA expression profile between the visceral white adipose tissue and the skeletal muscle of people with obesity undergoing bariatric surgery.<h4>Methods</h4>Skeletal muscle and visceral adipose tissue samples of 10 controls and 38 people with obesity (50% also with type 2 diabetes) undergoing bariatric surgery were collected. miRNA expression profiles were analyzed using Next-Generation Sequencing and subsequently validated using RT-PCR.<h4>Results</h4>Approximately 69% of miRNAs showed similar expression in both tissues, however, 55 miRNAs were preferentially expressed in visceral adipose tissue and 53 in skeletal muscle. miR-122b-5p was uniquely identified in skeletal muscle, while miR-1-3p and miR-206 were upregulated in skeletal muscle. Conversely, miR-224-5p and miR-335-3p exhibited upregulation in visceral adipose tissue. Notably, distinctions related to the presence of type 2 diabetes were observed solely in the expression of miR-1-3p and miR-206 in visceral adipose tissue.<h4>Conclusions</h4>This is the first study unveiling distinct miRNA expression profiles in paired samples of visceral adipose tissue and skeletal muscle in humans. The identification of obesity-specific miRNAs in these tissues opens up promising avenues for research into potential biomarkers for obesity diagnosis and treatment.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T20:42:18.383Z","creation":"2025-07-03T03:06:51.398Z"},"accession":"S-EPMC11999863","cross_references":{"pubmed":["39562687"],"doi":["10.1038/s41366-024-01683-4"]}}