{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Karamchandani RR"],"pubmed_abstract":["BackgroundFunctional outcomes in elderly thrombectomy patients have been commonly reported up to 90 days, though long-term neurological status is not as well characterized. We studied 1-year outcomes in patients ≥ 80 years old and identified predictors of functional independence in elderly patients.MethodsRetrospective analysis of anterior circulation thrombectomy patients presenting from November 2016-August 2023 to a large health system. The primary outcome was 1-year modified Rankin Scale score (mRS) 0-2. Outcomes were compared between patients ≥ 80 and < 80 years old. Logistic regression was performed to identify predictors of 1-year functional independence in the elderly.Results957 patients were included, 220 (23%) of whom were ≥ 80 years old. A significantly lower proportion of patients ≥ 80 years old, compared to < 80 years, were functionally independent at 1-year (18.6% versus 45.9%, p < 0.001). In the elderly, predictors of functional independence included age (odds ratio (OR) 0.83, 95% confidence interval (CI) 0.74-0.93, p = 0.002), premorbid mRS score (OR 0.51, 95% CI 0.29-0.88, p = 0.016), presenting National Institutes of Health Stroke Scale score (OR 0.93, 95% CI 0.87-0.995, p = 0.035), cerebral blood volume index (OR 50.7, 95% CI 2.8-935, p = 0.008), and first-pass recanalization (OR 2.77, 95% CI 1.20-6.38, p = 0.017).ConclusionElderly thrombectomy patients had lower rates of functional independence at 1-year, though these are similar to previously reported rates at 90-days in octogenarians and nonagenarians. Factors associated with good outcomes in the elderly, including collateral status and single-pass revascularization, may be prognostically informative beyond the 90-day time window."],"journal":["Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences"],"pagination":["15910199251332407"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11999982"],"repository":["biostudies-literature"],"pubmed_title":["Long-term functional outcomes for elderly patients treated with endovascular thrombectomy."],"pmcid":["PMC11999982"],"pubmed_authors":["Yang H","Williams L","Hines AU","Retelski J","Defilipp G","Guzik AK","Parish JM","Patel HN","Macko L","Teli KJ","Strong D","Patel NM","Stetler WR","Rhoten JB","Bernard JD","Patel ST","Wolfe SQ","Asimos AW","Karamchandani RR","Helms AM","Clemente JD"],"additional_accession":[]},"is_claimable":false,"name":"Long-term functional outcomes for elderly patients treated with endovascular thrombectomy.","description":"BackgroundFunctional outcomes in elderly thrombectomy patients have been commonly reported up to 90 days, though long-term neurological status is not as well characterized. We studied 1-year outcomes in patients ≥ 80 years old and identified predictors of functional independence in elderly patients.MethodsRetrospective analysis of anterior circulation thrombectomy patients presenting from November 2016-August 2023 to a large health system. The primary outcome was 1-year modified Rankin Scale score (mRS) 0-2. Outcomes were compared between patients ≥ 80 and < 80 years old. Logistic regression was performed to identify predictors of 1-year functional independence in the elderly.Results957 patients were included, 220 (23%) of whom were ≥ 80 years old. A significantly lower proportion of patients ≥ 80 years old, compared to < 80 years, were functionally independent at 1-year (18.6% versus 45.9%, p < 0.001). In the elderly, predictors of functional independence included age (odds ratio (OR) 0.83, 95% confidence interval (CI) 0.74-0.93, p = 0.002), premorbid mRS score (OR 0.51, 95% CI 0.29-0.88, p = 0.016), presenting National Institutes of Health Stroke Scale score (OR 0.93, 95% CI 0.87-0.995, p = 0.035), cerebral blood volume index (OR 50.7, 95% CI 2.8-935, p = 0.008), and first-pass recanalization (OR 2.77, 95% CI 1.20-6.38, p = 0.017).ConclusionElderly thrombectomy patients had lower rates of functional independence at 1-year, though these are similar to previously reported rates at 90-days in octogenarians and nonagenarians. Factors associated with good outcomes in the elderly, including collateral status and single-pass revascularization, may be prognostically informative beyond the 90-day time window.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-04-08T19:17:53.029Z","creation":"2025-07-14T03:02:46.476Z"},"accession":"S-EPMC11999982","cross_references":{"pubmed":["40232303"],"doi":["10.1177/15910199251332407"]}}