{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zaman A"],"funding":["NIA NIH HHS","National Institute on Aging"],"pagination":["e5903"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12000893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(4)"],"pubmed_abstract":["<h4>Objective</h4>Memory and cognitive problems are central to the diagnosis of Alzheimer's disease (AD). Psychometric approaches to defining phenotypes can aid in identify genetic variants associated with AD. However, these approaches have mostly been limited to affected individuals. Defining phenotypes of both affected and unaffected individuals may help identify genetic variants associated with both AD and healthy aging. This study compares psychometric methods for developing cognitive phenotypes that are more granular than clinical classifications.<h4>Methods</h4>682 older Old Order Amish individuals were included in the analysis. Adjusted Z-scores of cognitive tests were used to create four models including (1) global threshold scores or (2) memory threshold scores, and (3) global clu"],"journal":["International journal of geriatric psychiatry"],"pubmed_title":["Psychometric approaches to defining cognitive phenotypes in the Old Order Amish."],"pmcid":["PMC12000893"],"funding_grant_id":["R01 AG058066"],"pubmed_authors":["Fuzzell S","Vance JM","Clouse J","Haines JL","Pericak-Vance MA","Cuccaro ML","Zaman A","Hochstetler SD","Ogrocki P","Harrington S","Adams L","Fuzzell D","Laux R","Lerner A","Caywood L","Prough M","Scott WK"],"additional_accession":[]},"is_claimable":false,"name":"Psychometric approaches to defining cognitive phenotypes in the Old Order Amish.","description":"<h4>Objective</h4>Memory and cognitive problems are central to the diagnosis of Alzheimer's disease (AD). Psychometric approaches to defining phenotypes can aid in identify genetic variants associated with AD. However, these approaches have mostly been limited to affected individuals. Defining phenotypes of both affected and unaffected individuals may help identify genetic variants associated with both AD and healthy aging. This study compares psychometric methods for developing cognitive phenotypes that are more granular than clinical classifications.<h4>Methods</h4>682 older Old Order Amish individuals were included in the analysis. Adjusted Z-scores of cognitive tests were used to create four models including (1) global threshold scores or (2) memory threshold scores, and (3) global clu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-07-14T03:02:41.922Z","creation":"2025-07-14T03:02:41.922Z"},"accession":"S-EPMC12000893","cross_references":{"pubmed":["36929524"],"doi":["10.1002/gps.5903"]}}