{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["102(36)"],"submitter":["Rohrlich PS"],"pubmed_abstract":["Crystallographic analysis of human Hfe has documented an overall structure similar to classical (class Ia) MHC molecules with a peptide binding groove deprived of ligand. Thus, to address the question of whether alphabeta T cells could recognize MHC molecules independently of bound ligands, we studied human and mouse Hfe interactions with T lymphocytes. We provide formal evidence of direct cytolytic recognition of human Hfe by mouse alphabeta T cell receptors (TCR) in HLA-A*0201 transgenic mice and that this interaction results in ZAP-70 phosphorylation. Furthermore, direct recognition of mouse Hfe molecules by cytotoxic T lymphocytes (CTLs) was demonstrated in DBA/2 Hfe knockout mice. These CTLs express predominantly two T cell antigen receptor alpha variable gene segments (AV6.1 and AV6."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["12855-60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1200262"],"repository":["biostudies-literature"],"pubmed_title":["Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function."],"pmcid":["PMC1200262"],"pubmed_authors":["Charneau P","Fazilleau N","Pascolo S","Coppin H","Rohrlich PS","Lemonnier FA","Roth MP","Laham N","Michel F","Ginhoux F","Nato F","Danos O","Cochet M","Acuto O","Ehrlich R","Kanellopoulos J","Firat H"],"additional_accession":[]},"is_claimable":false,"name":"Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.","description":"Crystallographic analysis of human Hfe has documented an overall structure similar to classical (class Ia) MHC molecules with a peptide binding groove deprived of ligand. Thus, to address the question of whether alphabeta T cells could recognize MHC molecules independently of bound ligands, we studied human and mouse Hfe interactions with T lymphocytes. We provide formal evidence of direct cytolytic recognition of human Hfe by mouse alphabeta T cell receptors (TCR) in HLA-A*0201 transgenic mice and that this interaction results in ZAP-70 phosphorylation. Furthermore, direct recognition of mouse Hfe molecules by cytotoxic T lymphocytes (CTLs) was demonstrated in DBA/2 Hfe knockout mice. These CTLs express predominantly two T cell antigen receptor alpha variable gene segments (AV6.1 and AV6.","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Sep","modification":"2025-04-05T11:22:08.525Z","creation":"2019-03-27T01:09:20Z"},"accession":"S-EPMC1200262","cross_references":{"pubmed":["16123136"],"doi":["10.1073/pnas.0502309102"]}}