{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khawaja RR"],"funding":["NIA NIH HHS","NIDDK NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)","U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)","Instituto Carlos Slim de la Salud (Carlos Slim Health Institute)","U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)","JPB Foundation","Ministerio de Ciencia Tecnología y Telecomunicaciones (Ministerio de Ciencia Tecnología y Telecomunicaciones de Costa Rica)","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)","NIGMS NIH HHS"],"pagination":["691-708"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12003181"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(4)"],"pubmed_abstract":["Aging leads to progressive decline in organ and tissue integrity and function, partly due to loss of proteostasis and autophagy malfunctioning. A decrease with age in chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation, has been reported in various organs and cells from rodents and humans. Disruption of CMA recapitulates features of aging, whereas activating CMA in mice protects against age-related diseases such as Alzheimer's, retinal degeneration and/or atherosclerosis. However, sex-specific and cell-type-specific differences in CMA with aging remain unexplored. Here, using CMA reporter mice and single-cell transcriptomic data, we report that most organs and cell types show CMA decline with age, with males exhibiting a greater decline with aging. Reduced CMA is "],"journal":["Nature aging"],"pubmed_title":["Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging."],"pmcid":["PMC12003181"],"funding_grant_id":["N/A","AG054108","R01 DK124308","IRACDA-BETTR","Margarita Salas Contract","T32AG023475","R37 AG021904","RF1 AG054108","R01 AG021904","T32GM007491","P01 AG031782","R01 DK098408","T32 GM007491","AG021904","T32 AG023475","PID2021-126864NB I00","DK124308","F31 AG08419","AG031782","F31 AG084192","DK098408"],"pubmed_authors":["Gomez-Sintes R","Martin-Segura A","Macho-Gonzalez A","Tasset I","Xie X","Sereda R","Khawaja RR","Santiago-Fernandez O","Kim M","Scrivo A","Chavda B","Saez-Ibanez AR","Kaushik S","Cuervo AM","Jafari M","McCabe M","Arias E","Lindenau K"],"additional_accession":[]},"is_claimable":false,"name":"Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging.","description":"Aging leads to progressive decline in organ and tissue integrity and function, partly due to loss of proteostasis and autophagy malfunctioning. A decrease with age in chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation, has been reported in various organs and cells from rodents and humans. Disruption of CMA recapitulates features of aging, whereas activating CMA in mice protects against age-related diseases such as Alzheimer's, retinal degeneration and/or atherosclerosis. However, sex-specific and cell-type-specific differences in CMA with aging remain unexplored. Here, using CMA reporter mice and single-cell transcriptomic data, we report that most organs and cell types show CMA decline with age, with males exhibiting a greater decline with aging. Reduced CMA is ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-04T03:06:17.591Z","creation":"2025-07-04T03:06:17.591Z"},"accession":"S-EPMC12003181","cross_references":{"pubmed":["39910244"],"doi":["10.1038/s43587-024-00799-6"]}}