{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lang J"],"funding":["Western Australian State Government, and the MRFF","Murdoch University","Agencia Estatal de Investigación","Department of Jobs, Tourism, Science and Innovation, Government of Western Australia"],"pagination":["421-433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12003606"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["103(4)"],"pubmed_abstract":["COVID-19 vaccines are crucial in reducing SARS-CoV-2 transmission and severe health outcomes. Despite widespread administration, their long-term systemic effects on human metabolism remain inadequately understood. This longitudinal study aims to evaluate IgG responses, 34 cytokines, 112 lipoproteins, and 21 low-molecular-weight metabolites in 33 individuals receiving two to four COVID-19 vaccine doses. Changes in metabolic profiles for the first 16 days post each dose of vaccine, and up to 480 days post-initial dose, were compared to baseline (before vaccination). Additionally, metabolic profiles of vaccinated participants were compared to a reference cohort of unvaccinated individuals without prior exposure to SARS-CoV-2 infection (controls) and SARS-CoV-2 cases. Positive IgG responses we"],"journal":["Journal of molecular medicine (Berlin, Germany)"],"pubmed_title":["Longitudinal study on immunologic, lipoproteomic, and inflammatory responses indicates the safety of sequential COVID-19 vaccination."],"pmcid":["PMC12003606"],"funding_grant_id":["PID2021-124171OB-I00","2014349"],"pubmed_authors":["Lang J","Ryan M","Nitschke P","Bernal A","Bong SH","Wist J","Millet O","Loo RL","Egan S","Imrie A","Masuda R","Holmes E","Nicholson J","Lee AC","Hall D"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal study on immunologic, lipoproteomic, and inflammatory responses indicates the safety of sequential COVID-19 vaccination.","description":"COVID-19 vaccines are crucial in reducing SARS-CoV-2 transmission and severe health outcomes. Despite widespread administration, their long-term systemic effects on human metabolism remain inadequately understood. This longitudinal study aims to evaluate IgG responses, 34 cytokines, 112 lipoproteins, and 21 low-molecular-weight metabolites in 33 individuals receiving two to four COVID-19 vaccine doses. Changes in metabolic profiles for the first 16 days post each dose of vaccine, and up to 480 days post-initial dose, were compared to baseline (before vaccination). Additionally, metabolic profiles of vaccinated participants were compared to a reference cohort of unvaccinated individuals without prior exposure to SARS-CoV-2 infection (controls) and SARS-CoV-2 cases. Positive IgG responses we","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-03T03:04:42.899Z","creation":"2025-07-03T03:04:42.899Z"},"accession":"S-EPMC12003606","cross_references":{"pubmed":["40074874"],"doi":["10.1007/s00109-025-02527-y"]}}