biostudies-literatureUnknown12(1)Tsai CK<h4>Background</h4>This study aimed to investigate the frequently overlooked symptoms of cold hypersensitivity and heavy legs related to varicose veins in a large sample of patients.<h4>Methods</h4>Data on 8782 adults aged 30-70 years without a history of cancer were sourced from the Taiwan Biobank between 2008 and 2020. Varicose veins, cold hypersensitivity and heavy leg sensations were assessed using questionnaires and analysed using logistic regression models with various covariates. Statistical analyses were performed, with analysis of variance for continuous variables and χ² tests for categorical variables at a significance level of 0.05.<h4>Results</h4>Our analysis showed significant associations between varicose veins, cold hypersensitivity, and heavy legs (p<0.0001). LogOpen hearte002909https://www.ebi.ac.uk/biostudies/studies/S-EPMC12004473biostudies-literatureCold hypersensitivity in the lower extremities: an underappreciated symptom in patients with varicose veins.PMC12004473Nfor ONLiaw YPWu HYLu WYTsai CKTantoh DMfalseCold hypersensitivity in the lower extremities: an underappreciated symptom in patients with varicose veins.<h4>Background</h4>This study aimed to investigate the frequently overlooked symptoms of cold hypersensitivity and heavy legs related to varicose veins in a large sample of patients.<h4>Methods</h4>Data on 8782 adults aged 30-70 years without a history of cancer were sourced from the Taiwan Biobank between 2008 and 2020. Varicose veins, cold hypersensitivity and heavy leg sensations were assessed using questionnaires and analysed using logistic regression models with various covariates. Statistical analyses were performed, with analysis of variance for continuous variables and χ² tests for categorical variables at a significance level of 0.05.<h4>Results</h4>Our analysis showed significant associations between varicose veins, cold hypersensitivity, and heavy legs (p<0.0001). Log2025-01-01T00:00:00Z2025 Apr2025-07-14T03:02:41.699Z2025-07-14T03:02:41.699ZS-EPMC120044734023408510.1136/openhrt-2024-002909