{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tong R"],"funding":["National Natural Science Foundation of China","Reform and Development Program of Beijing Institute of Respiratory Medicine","Postdoctoral Fellowship Program of CPSF"],"pagination":["74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12004876"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>Recent observational studies have revealed an inconclusive correlation between inflammatory bowel disease (IBD) and sepsis, accompanied by an uncertain understanding of the causal relationship between the two. To investigate the causality between IBD and sepsis, we employed a two-sample Mendelian randomization (MR) approach.<h4>Methods</h4>A genome-wide significant threshold (P < 5 × 10<sup>-8</sup>) was achieved in order to identify single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for two types of IBD, such as Crohn's disease (CD) and ulcerative colitis (UC). Subsequently, the selected SNPs were assessed in relation to three categories of sepsis, namely sepsis, sepsis (critical care), and sepsis (28-day death in critical care). An inverse-variance "],"journal":["BMC medical genomics"],"pubmed_title":["Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study."],"pmcid":["PMC12004876"],"funding_grant_id":["Ggyfz202515","82000262","GZC20241101"],"pubmed_authors":["Tong R","Xu L","Yu L","Dao L","Liang Z","Tong Z","Du Y","Bai X","Li L","Zhuo C"],"additional_accession":[]},"is_claimable":false,"name":"Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study.","description":"<h4>Background</h4>Recent observational studies have revealed an inconclusive correlation between inflammatory bowel disease (IBD) and sepsis, accompanied by an uncertain understanding of the causal relationship between the two. To investigate the causality between IBD and sepsis, we employed a two-sample Mendelian randomization (MR) approach.<h4>Methods</h4>A genome-wide significant threshold (P < 5 × 10<sup>-8</sup>) was achieved in order to identify single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for two types of IBD, such as Crohn's disease (CD) and ulcerative colitis (UC). Subsequently, the selected SNPs were assessed in relation to three categories of sepsis, namely sepsis, sepsis (critical care), and sepsis (28-day death in critical care). An inverse-variance ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T10:20:28.083Z","creation":"2026-04-08T11:18:53.068Z"},"accession":"S-EPMC12004876","cross_references":{"pubmed":["40247302"],"doi":["10.1186/s12920-025-02143-2"]}}