biostudies-literatureUnknown7(5)Sala M<h4>Background & aims</h4>The epidemiological landscape of hepatocellular carcinoma (HCC) in Europe is evolving. This study aims to provide an updated description of the current epidemiology of liver cancer in Spain.<h4>Methods</h4>This multicenter prospective study collected demographic and clinical data on primary liver cancer between October 2022 and January 2023. We conducted descriptive and comparative analyses with data collected in 2008 and 2014.<h4>Results</h4>Of the 767 cases of primary liver cancer collected from 52 centers, 91% were diagnosed as HCC. The majority of patients were male (83.3%), average age 68 years, 80.7% had cirrhosis. The primary causes were alcohol (29.9% alone, 55% combined with other etiologies), liver disease related to metabolic syndrome (LDrMS, 23%) and hJHEP reports : innovation in hepatology101336https://www.ebi.ac.uk/biostudies/studies/S-EPMC12005282biostudies-literatureEvolving epidemiology of HCC in Spain.PMC12005282Cachero ARomero-Gutierrez MGuerrero AMolina EHernaez-Alsina TRodriguez-Gonzalez MMVarela MCastro RQVergara MGiraldez ADelgado MVallejo-Senra NRodriguez-Lope COlmo JFGuerrero MSerra HALue APacheco Del Rio GColl SDelgado CMontoliu SFernandez-Marcos CSerra IFerrer MTLlamoza-Torres CJFernandez-Bermejo MCortes-Garcia LSanchez AGGacho PCReig MRamos ICCampos MValer Lopez-Fando MPPascual SBustamante JBermudez-Ramos MRodriguez MCuyas BRoget MDiaz-Gonzalez AMacias-Rodriguez MAMatilla AMFernandez-Lopez AMPenas ILledo JLHernandez-Guerra MSegarra JXBarrio MLGomez-Rubio MChiminazzo VMorillas MJGutierrez-Garcia MLRifa RMontero JLAracil CRota Roca MRUrquijo Ponce JJInarrairaegui MDiaz-Bethencourt DOlmedo SRUnceta PRGonzalez-Santiago JMGuiberteau ASogbe MClos AVazquez-Rodriguez SMinguez BPerello CLazaro MSala MfalseEvolving epidemiology of HCC in Spain.<h4>Background & aims</h4>The epidemiological landscape of hepatocellular carcinoma (HCC) in Europe is evolving. This study aims to provide an updated description of the current epidemiology of liver cancer in Spain.<h4>Methods</h4>This multicenter prospective study collected demographic and clinical data on primary liver cancer between October 2022 and January 2023. We conducted descriptive and comparative analyses with data collected in 2008 and 2014.<h4>Results</h4>Of the 767 cases of primary liver cancer collected from 52 centers, 91% were diagnosed as HCC. The majority of patients were male (83.3%), average age 68 years, 80.7% had cirrhosis. The primary causes were alcohol (29.9% alone, 55% combined with other etiologies), liver disease related to metabolic syndrome (LDrMS, 23%) and h2025-01-01T00:00:00Z2025 May2025-07-08T03:11:13.97Z2025-07-08T03:11:13.97ZS-EPMC120052824024860510.1016/j.jhepr.2025.101336