{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shelton MA"],"funding":["Association of Academic Physiatrists","NIDA NIH HHS","University of Pittsburgh","NHLBI NIH HHS","National Institutes of Health","National Heart Lung and Blood Institute","National Institute on Drug Abuse"],"pagination":["100476"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12005289"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(3)"],"pubmed_abstract":["<h4>Background</h4>Opioid use disorder (OUD) has emerged as a severe, ongoing public health emergency. Current treatments for OUD are unsuccessful in leading to lasting abstinence in most users. This underscores the lasting effects of chronic opioid use and emphasizes the need to understand the molecular mechanisms of drug seeking and taking and how those alterations persist through acute and protracted withdrawal.<h4>Methods</h4>Here, we used RNA sequencing in postmortem human tissue from males (<i>n</i> = 10) and females (<i>n</i> = 10) with OUD and age- and sex-matched control subjects. We compared molecular alterations associated with human OUD in the nucleus accumbens (NAc) to mouse and rat models of nonvolitional (<i>n</i> = 4-5 per group per sex) and volitional (<i>n</i> = 5-6 per g"],"journal":["Biological psychiatry global open science"],"pubmed_title":["Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains."],"pmcid":["PMC12005289"],"funding_grant_id":["R01DA051390","R01HL150432","U01DA044451","R21 DA058174","R01 HL150432","U01 DA044451","R21DA058174","R01 DA051390"],"pubmed_authors":["Solberg Woods LC","Gamble MC","Fish MK","Michaud J","George O","Shelton MA","Blendy JA","Eacret D","Logan RW","Xue X","Phan BN","Maturin L","Singh N","Horan N","Palmer AA","Seggio JA","Tseng GC","Seney ML","Williams BR"],"additional_accession":[]},"is_claimable":false,"name":"Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains.","description":"<h4>Background</h4>Opioid use disorder (OUD) has emerged as a severe, ongoing public health emergency. Current treatments for OUD are unsuccessful in leading to lasting abstinence in most users. This underscores the lasting effects of chronic opioid use and emphasizes the need to understand the molecular mechanisms of drug seeking and taking and how those alterations persist through acute and protracted withdrawal.<h4>Methods</h4>Here, we used RNA sequencing in postmortem human tissue from males (<i>n</i> = 10) and females (<i>n</i> = 10) with OUD and age- and sex-matched control subjects. We compared molecular alterations associated with human OUD in the nucleus accumbens (NAc) to mouse and rat models of nonvolitional (<i>n</i> = 4-5 per group per sex) and volitional (<i>n</i> = 5-6 per g","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T05:19:08.77Z","creation":"2026-04-08T09:25:09.718Z"},"accession":"S-EPMC12005289","cross_references":{"pubmed":["40248277"],"doi":["10.1016/j.bpsgos.2025.100476"]}}