biostudies-literatureUnknown29(1)Maia IWA<h4>Background</h4>Emergency tracheal intubation in critically ill patients carries a high risk of complications, and practices vary substantially across different settings. Identifying risk factors and understanding how peri-intubation adverse events affect patient outcomes may guide standardization of care and improve survival.<h4>Methods</h4>This prospective cohort study involved 18 emergency departments in Brazil (March 2022-April 2024). We included adults (≥ 18 years) undergoing emergency intubation and excluded patients intubated electively or for cardiac arrest. We defined major peri-intubation adverse events as severe hypoxemia, new hemodynamic instability, or cardiac arrest occurring within 30 min of initiating intubation. The primary outcome was 28-day mortality. Multivariable reCritical care (London, England)155https://www.ebi.ac.uk/biostudies/studies/S-EPMC12007353biostudies-literaturePeri-intubation adverse events and clinical outcomes in emergency department patients: the BARCO study.PMC12007353Dias GLima ILBorges VBaumgratz TDda Silva Castro Vvon Hellmann RMartins DMullan APedrollo DFMelo RFilho UAVCosta DNogueira CGBellolio Fda Cunha VPSilveira SWeber APMotta JCGasperini LHajjar LAFigueiredo NMPAlencar JCGSilva SMCamara VAAReis APRRosa DACde Carvalho JMDFreitas APSouza HPZanettini JCosta MCde Maria RGMaiante AASilva LOJECorreia WSudbrack TRGuimaraes HPFuhr NGaspar PLFreitas ARathke JBARCO groupMoreira NPMarchini JFRibeiro APGava TFde Oliveira CMRMoura PAdo Carmo GHAZanella VCVarela LFBesen BAMPColleoni OKonrath ALKai RYValdivia JSandefur BJJunior ELFde Vargas Tomelero ABertotto HMiranda CHChimelli GTARJeffery MMde Carvalho Rufato TBaldino IGreco FPoloni VSTabach BSRischini FZenly HMaia IWARanzani OTFilippo YLima KDornelles CFDStanzani GMiranda GBergesch BZimerman ATambelli RfalsePeri-intubation adverse events and clinical outcomes in emergency department patients: the BARCO study.<h4>Background</h4>Emergency tracheal intubation in critically ill patients carries a high risk of complications, and practices vary substantially across different settings. Identifying risk factors and understanding how peri-intubation adverse events affect patient outcomes may guide standardization of care and improve survival.<h4>Methods</h4>This prospective cohort study involved 18 emergency departments in Brazil (March 2022-April 2024). We included adults (≥ 18 years) undergoing emergency intubation and excluded patients intubated electively or for cardiac arrest. We defined major peri-intubation adverse events as severe hypoxemia, new hemodynamic instability, or cardiac arrest occurring within 30 min of initiating intubation. The primary outcome was 28-day mortality. Multivariable re2025-01-01T00:00:00Z2025 Apr2026-06-02T06:43:20.626Z2026-05-25T03:08:02.754ZS-EPMC120073534024738110.1186/s13054-025-05392-w