{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo Y"],"funding":["Guangdong Provincial Department of Science and Technology","National Natural Science Foundation of China","the Deng Feng Project of First People's Hospital of Foshan","the Deng Feng Project of First People’s Hospital of Foshan"],"pagination":["13377"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12008296"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Caerin peptides exhibit a dual role in cancer treatment by directly killing cancer cells and modulating the tumour microenvironment to enhance anti-tumour immunity. This study investigates the mechanisms underlying caerin 1.1/1.9-induced acute cell death in epithelial cancer cells and explores their therapeutic potential. HeLa, A549, and Huh-7 cancer cell lines were treated with caerin 1.1/1.9 peptides. Morphological observations, flow cytometry, lactate dehydrogenase (LDH) release, and IL-18 secretion assays revealed the occurrence of pyroptosis following treatment. Specifically, a 1-h treatment with caerin 1.1/1.9 induced pyroptosis in HeLa, A549, and Huh-7 cells, characterised by cell swelling, membrane bubbling, and the release of IL-18 and LDH. Western blotting confirmed the upregulat"],"journal":["Scientific reports"],"pubmed_title":["Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells."],"pmcid":["PMC12008296"],"funding_grant_id":["31971355","2016A020213001","2019A008"],"pubmed_authors":["Fu Q","Wu J","Li J","Liu M","Ni G","Zhang P","Mo R","Yang X","Liu X","Wang T","Fu J","Tang S","Luo Y","Song X"],"additional_accession":[]},"is_claimable":false,"name":"Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells.","description":"Caerin peptides exhibit a dual role in cancer treatment by directly killing cancer cells and modulating the tumour microenvironment to enhance anti-tumour immunity. This study investigates the mechanisms underlying caerin 1.1/1.9-induced acute cell death in epithelial cancer cells and explores their therapeutic potential. HeLa, A549, and Huh-7 cancer cell lines were treated with caerin 1.1/1.9 peptides. Morphological observations, flow cytometry, lactate dehydrogenase (LDH) release, and IL-18 secretion assays revealed the occurrence of pyroptosis following treatment. Specifically, a 1-h treatment with caerin 1.1/1.9 induced pyroptosis in HeLa, A549, and Huh-7 cells, characterised by cell swelling, membrane bubbling, and the release of IL-18 and LDH. Western blotting confirmed the upregulat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-06-28T03:05:31.876Z","creation":"2025-06-28T03:05:31.876Z"},"accession":"S-EPMC12008296","cross_references":{"pubmed":["40251208"],"doi":["10.1038/s41598-025-96438-0"]}}