{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["PENGUIN Trial Management Groupj.glasbey@bham.ac.uk23cgeorge@gmail.com"],"funding":["National Institute for Health Research (NIHR)","National Institute for Health and Care Research"],"pagination":["100396"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12008669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["<h4>Background</h4>Infections are a common complication of abdominal surgery in low- and middle-income countries (LMICs). The role of a high fraction of inspired oxygen (FiO<sub>2</sub>) and chlorhexidine mouthwash in preventing post-operative infections is unconfirmed.<h4>Methods</h4>Internal pilot phase of an international outcome assessor-blinded, 2x2 factorial randomised trial of patients aged ≥10-years undergoing midline laparotomy in LMIC hospitals. The main trial objectives are to compare the clinical effectiveness of preoperative 0.2% chlorhexidine mouthwash in preventing pneumonia versus no mouthwash, and 80-100% perioperative FiO<sub>2</sub> to prevent surgical site infection (SSI) versus 21-35% FiO<sub>2</sub>. This 12-month internal pilot assessed feasibility of hospital site o"],"journal":["BJA open"],"pubmed_title":["PErioperative respiratory care aNd outcomes for patients underGoing hIgh risk abdomiNal surgery (PENGUIN): a randomised international internal pilot trial."],"pmcid":["PMC12008669"],"funding_grant_id":["NIHR300175","16.136.79"],"pubmed_authors":["Gumede SW","Balija SS","Haque PD","Lillywhite R","Garry GK","Mahajan A","Kadir B","Shajahan S","Martin J","Crawford R","Dhamija P","Kapoor D","Goswami J","Seenivasagam RK","Patro V","Hans P","Jain D","Rathod KK","Rajappa R","Wilson GS","Pearse R","Singh SK","Soden M","George C","Desai N","Boutall AB","Mathai S","PENGUIN Trial Management Group","Bannister SJ","Jhanji S","NIHR Global Health Research Unit on Global Surgery Collaborators","PENGUIN Trial Management Groupj.glasbey@bham.ac.uk23cgeorge@gmail.com","Ghosh D","Thind RS","Goyal A","Vishnoi JR","Tabiri S","Morton D","Dhiman J","Chakrabortee S","Kaur H","Lawani I","Laurberg S","Cousens S","Bhangu A","Suroy A","Rayamajhi S","Roberts T","Michael V","Runigamugabo E","Chaudhary R","Kothari N","Biccard B","Daniel S","Joshva M","Kumar P","Haque P","Ghosh DN","Goyal S","Daniel N","Rodha MS","Poonia DR","Sentholang N","Glasbey J","Sharma N","Tripathi DK","Sharma S","Sanchez ID","Smart N","Hudda F","Misra S","Rajkumar A","Winkles N","Aggarwal M","Pareek P","Bhatt A","Hardy P","Varshney VK","Jakhar R","Chandra Soni S","Chowdhury S","Bhatia PK","Vazquez DG","Schultz M","Kachapila M","Talwar P","Omar O","Smith D","Perez Maldonado LM","Biccard BM","Moore R","Lara MM","Ademuyiwa A","Flint MG","Magill L","Leslie K","Ramos-De la Medina A","Brown J","Kumar K","Fourtounas M","Kumar A","Yu LM"],"additional_accession":[]},"is_claimable":false,"name":"PErioperative respiratory care aNd outcomes for patients underGoing hIgh risk abdomiNal surgery (PENGUIN): a randomised international internal pilot trial.","description":"<h4>Background</h4>Infections are a common complication of abdominal surgery in low- and middle-income countries (LMICs). The role of a high fraction of inspired oxygen (FiO<sub>2</sub>) and chlorhexidine mouthwash in preventing post-operative infections is unconfirmed.<h4>Methods</h4>Internal pilot phase of an international outcome assessor-blinded, 2x2 factorial randomised trial of patients aged ≥10-years undergoing midline laparotomy in LMIC hospitals. The main trial objectives are to compare the clinical effectiveness of preoperative 0.2% chlorhexidine mouthwash in preventing pneumonia versus no mouthwash, and 80-100% perioperative FiO<sub>2</sub> to prevent surgical site infection (SSI) versus 21-35% FiO<sub>2</sub>. This 12-month internal pilot assessed feasibility of hospital site o","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-05-02T14:20:49.771Z","creation":"2025-07-03T03:05:05.186Z"},"accession":"S-EPMC12008669","cross_references":{"pubmed":["40255646"],"doi":["10.1016/j.bjao.2025.100396"]}}