{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeong YJ"],"funding":["Yonsei University College of Medicine","Commercializations Promotion Agency for R and D Outcomes","Ministry of Science and ICT, South Korea"],"pagination":["187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12008940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Salivary gland (SG) hypofunction presents a significant clinical challenge with limited treatment options. SG epithelial cells offer a promising approach due to their intrinsic tissue specificity and regenerative potential. However, the lack of efficient culture methods has hindered their clinical use.<h4>Methods</h4>This study presents a chemical reprogramming culture (CRC) system that utilizes a combination of three small molecules for the long-term two-dimensional culture of human SG epithelial progenitor cells. We characterized the cultured cells, measured their organoid-forming efficiencies, and assessed their differentiation potential. To evaluate the therapeutic efficacy of the SG basal progenitor cells (SG-BPCs), we administered them into a mouse model with radia"],"journal":["Stem cell research & therapy"],"pubmed_title":["Chemical reprogramming culture for the expansion of salivary gland epithelial basal progenitor cells."],"pmcid":["PMC12008940"],"funding_grant_id":["RS-2022-00164878","6-2022-0106","RS-2024-00432946"],"pubmed_authors":["Hong SM","Hong Y","Sim NS","Lim JY","Jeong YJ","Yoon YJ"],"additional_accession":[]},"is_claimable":false,"name":"Chemical reprogramming culture for the expansion of salivary gland epithelial basal progenitor cells.","description":"<h4>Background</h4>Salivary gland (SG) hypofunction presents a significant clinical challenge with limited treatment options. SG epithelial cells offer a promising approach due to their intrinsic tissue specificity and regenerative potential. However, the lack of efficient culture methods has hindered their clinical use.<h4>Methods</h4>This study presents a chemical reprogramming culture (CRC) system that utilizes a combination of three small molecules for the long-term two-dimensional culture of human SG epithelial progenitor cells. We characterized the cultured cells, measured their organoid-forming efficiencies, and assessed their differentiation potential. To evaluate the therapeutic efficacy of the SG basal progenitor cells (SG-BPCs), we administered them into a mouse model with radia","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-06-28T03:05:34.844Z","creation":"2025-06-28T03:05:34.844Z"},"accession":"S-EPMC12008940","cross_references":{"pubmed":["40251601"],"doi":["10.1186/s13287-025-04295-5"]}}