{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu D"],"funding":["the \"Shu-Guang Scholar Programme\" from Shanghai Municipal Education Commission, the \"Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support\" from Shanghai Jiao Tong University School of Medicine","National Key R&D Program of China","Noncommunicable Chronic Diseases-National Science and Technology Major Project","National Natural Science Foundation of China"],"pagination":["170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12008983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Background
Delineating the causal chain effects of reproductive traits and fat- and muscle-related traits on cardiovascular disease (CVD) is essential for optimizing precision prevention and control of cardiovascular health in women.Methods
In this study, we applied the two-sample Mendelian randomization (MR) analyses and two-step MR framework to investigate the causal chain effects and the mediating effect pathways among reproductive factors and fat- and muscle-related traits on CVD outcomes in women, applying the genome-wide association study summary statistics of 16 women's reproductive traits across puberty and pre-pregnancy, pregnancy and postpartum, and menopausal transition stages, 16 women's fat- and muscle-related traits, and five CVD outcomes of coronary artery di"],"journal":["Cardiovascular diabetology"],"pubmed_title":["Chain effect of lifecourse reproductive characteristics and body fat and muscle on cardiovascular disease in women: a Mendelian randomization study."],"pmcid":["PMC12008983"],"funding_grant_id":["20171901 Round 2","82370820, 82088102, and 81930021","2023ZD0508603","2023YFC2506700"],"pubmed_authors":["Kong L","Xu M","Zhu Z","Ye C","Chen M","Zhao Z","Li M","Ning G","Zheng J","Lu J","Wang T","Chen Y","Wang W","Liu D","Dou C","Xu Y","Bi Y"],"additional_accession":[]},"is_claimable":false,"name":"Chain effect of lifecourse reproductive characteristics and body fat and muscle on cardiovascular disease in women: a Mendelian randomization study.","description":"Background
Delineating the causal chain effects of reproductive traits and fat- and muscle-related traits on cardiovascular disease (CVD) is essential for optimizing precision prevention and control of cardiovascular health in women.Methods
In this study, we applied the two-sample Mendelian randomization (MR) analyses and two-step MR framework to investigate the causal chain effects and the mediating effect pathways among reproductive factors and fat- and muscle-related traits on CVD outcomes in women, applying the genome-wide association study summary statistics of 16 women's reproductive traits across puberty and pre-pregnancy, pregnancy and postpartum, and menopausal transition stages, 16 women's fat- and muscle-related traits, and five CVD outcomes of coronary artery di","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-03T03:04:53.163Z","creation":"2025-07-03T03:04:53.163Z"},"accession":"S-EPMC12008983","cross_references":{"pubmed":["40251560"],"doi":["10.1186/s12933-025-02681-0"]}}