biostudies-literatureZimmermann EADevelopmental Grant from the Shriners Hospitals for Children511-521https://www.ebi.ac.uk/biostudies/studies/S-EPMC12010165biostudies-literatureUnknown40(4)Cerebral palsy (CP) is a non-progressive neurological syndrome resulting in abnormal muscle tone, movement, and posture. It is unclear whether ambulatory children with CP have deficits in bone quantity or quality. Furthermore, the relationship between abnormal muscle tone, altered function, and bone health remains largely unexplored. This observational study investigated bone mineral density (BMD) and microarchitecture in ambulatory children with spastic CP and associations of BMD with function, muscle spasticity, and gait. Children with spasticity in both lower limbs (n = 12) aged 3-8 years were recruited. Areal BMD was measured with dual energy x-ray absorptiometry (DXA) at the proximal femur and lateral distal femur and compared to normative data. High resolution peripheral quantitativeJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchAmbulatory children with spastic cerebral palsy have smaller bone area and deficits in trabecular microarchitecture.PMC1201016572011-CAN-2072 011-CAN-20Farmer JPWillie BMVeilleux LNJulien CGagnon MYap RZimmermann EAHosseinitabatabaei SCarriero ARioux Trottier EAudet DfalseAmbulatory children with spastic cerebral palsy have smaller bone area and deficits in trabecular microarchitecture.Cerebral palsy (CP) is a non-progressive neurological syndrome resulting in abnormal muscle tone, movement, and posture. It is unclear whether ambulatory children with CP have deficits in bone quantity or quality. Furthermore, the relationship between abnormal muscle tone, altered function, and bone health remains largely unexplored. This observational study investigated bone mineral density (BMD) and microarchitecture in ambulatory children with spastic CP and associations of BMD with function, muscle spasticity, and gait. Children with spasticity in both lower limbs (n = 12) aged 3-8 years were recruited. Areal BMD was measured with dual energy x-ray absorptiometry (DXA) at the proximal femur and lateral distal femur and compared to normative data. High resolution peripheral quantitative2025-01-01T00:00:00Z2025 Apr2025-07-11T03:04:07.945Z2025-07-11T03:04:07.945ZS-EPMC120101653992793010.1093/jbmr/zjaf026