{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["S Mesquita F"],"funding":["Swiss National Science Foundation","NIGMS NIH HHS"],"pagination":["488-509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12010433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(6)"],"pubmed_abstract":["Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty acid to a protein. Maintenance of the equilibrium between protein S-acylation and deacylation has demonstrated profound effects on various cellular processes, including innate immunity, inflammation, glucose metabolism and fat metabolism, as well as on brain and heart function. This Review provides an overview of current understanding of S-acylation and deacylation enzymes, their spatiotemporal regulation by sophisticated multilayered mechanisms, and their influence on protein function, cellular processes and physiological pathways. Furthe"],"journal":["Nature reviews. Molecular cell biology"],"pubmed_title":["Mechanisms and functions of protein S-acylation."],"pmcid":["PMC12010433"],"funding_grant_id":["310030","R35 GM119840","192608","196651"],"pubmed_authors":["Dickinson BC","Bamji SX","Abrami L","Linder ME","van der Goot FG","S Mesquita F"],"additional_accession":[]},"is_claimable":false,"name":"Mechanisms and functions of protein S-acylation.","description":"Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty acid to a protein. Maintenance of the equilibrium between protein S-acylation and deacylation has demonstrated profound effects on various cellular processes, including innate immunity, inflammation, glucose metabolism and fat metabolism, as well as on brain and heart function. This Review provides an overview of current understanding of S-acylation and deacylation enzymes, their spatiotemporal regulation by sophisticated multilayered mechanisms, and their influence on protein function, cellular processes and physiological pathways. Furthe","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-01T11:39:41.965Z","creation":"2026-04-08T11:55:43.819Z"},"accession":"S-EPMC12010433","cross_references":{"pubmed":["38355760"],"doi":["10.1038/s41580-024-00700-8"]}}