biostudies-literatureHua SNatural Science Foundation of ShanghaiScientific research project of Jiangsu Provincial Health CommissionNational Natural Science Foundation of ChinaPostgraduate Scientific Research Innovation Program of Jiangsu ProvinceFoundation from Jiangsu Provincial Administration of Traditional Chinese MedicineNatural Science Foundation of Jiangsu Province264-274https://www.ebi.ac.uk/biostudies/studies/S-EPMC12010649biostudies-literatureUnknown63(1)<h4>Context</h4>Vascular inflammation is a key process in the pathogenesis of atherosclerosis, which is regulated by NF-κB pathway. Yiqi Wenyang decoction (YQWY), a Traditional Chinese medicine (TCM) formula, has anti-inflammatory properties and may inhibit this pathway, potentially offering anti-atherosclerotic effects.<h4>Objective</h4>The purpose of this study is to investigate the effects of YQWY on atherosclerosis and the underlying mechanism. Materials and methods: ApoE^-/- mice were fed a Western diet and administered with YQWY (low or high dose), atorvastatin, or vehicle for 13 weeks. The size of atherosclerotic plaques was assessed using ORO staining. Vascular inflammation was evaluated with IF or IHC staining. The mechanisms and signaling pathways underlying the effect Pharmaceutical biologyYiqi Wenyang decoction protects against the development of atherosclerosis by inhibiting vascular inflammation.PMC12010649BK20221422k2021j17-3M2021011KYCX23_2116ZT20210422ZR14304008177413482370865KYCX22_1937BK20221551BK20220739Sun LZhu YHuang ZJiang WZhang HShiu CHua SZhang SGu PYan XfalseYiqi Wenyang decoction protects against the development of atherosclerosis by inhibiting vascular inflammation.<h4>Context</h4>Vascular inflammation is a key process in the pathogenesis of atherosclerosis, which is regulated by NF-κB pathway. Yiqi Wenyang decoction (YQWY), a Traditional Chinese medicine (TCM) formula, has anti-inflammatory properties and may inhibit this pathway, potentially offering anti-atherosclerotic effects.<h4>Objective</h4>The purpose of this study is to investigate the effects of YQWY on atherosclerosis and the underlying mechanism. Materials and methods: ApoE^-/- mice were fed a Western diet and administered with YQWY (low or high dose), atorvastatin, or vehicle for 13 weeks. The size of atherosclerotic plaques was assessed using ORO staining. Vascular inflammation was evaluated with IF or IHC staining. The mechanisms and signaling pathways underlying the effect 2025-01-01T00:00:00Z2025 Dec2026-06-08T05:14:08.984Z2025-07-06T03:04:37.54ZS-EPMC120106494025471710.1080/13880209.2025.2492650