{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Wilks AW"],"pubmed_abstract":["<h4>Background</h4>Immune-mediated necrotizing myopathy (IMNM) and dermatomyositis (DM) are characterized by weakness, hyperCKemia, associated autoantibodies, and varying extramuscular manifestations. Muscle MRI, currently subordinate to histopathology and serology in idiopathic inflammatory myopathy (IIM) classification, has an evolving role. Our study aims to define thigh muscle MRI involvement in IMNM and DM by direct comparison.<h4>Methods</h4>This single-center, retrospective, cross-sectional study included 25 participants, who met IIM classification criteria (14 IMNM, 11 DM) and had available thigh MRI. Clinical and paraclinical data were available and reviewed. 11 muscles were graded for edema on MRI using a semi-quantitative scale (0: normal, 1: <30% of muscle involvement, 2: 31-75"],"journal":["BMC rheumatology"],"pagination":["46"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12010673"],"repository":["biostudies-literature"],"pubmed_title":["MRI patterns of thigh muscle involvement in immune-mediated necrotizing myopathy and dermatomyositis."],"pmcid":["PMC12010673"],"pubmed_authors":["Rooney WD","Choi D","Ghetie D","Chahin N","Vakil-Gilani KM","Wilks AW"],"additional_accession":[]},"is_claimable":false,"name":"MRI patterns of thigh muscle involvement in immune-mediated necrotizing myopathy and dermatomyositis.","description":"<h4>Background</h4>Immune-mediated necrotizing myopathy (IMNM) and dermatomyositis (DM) are characterized by weakness, hyperCKemia, associated autoantibodies, and varying extramuscular manifestations. Muscle MRI, currently subordinate to histopathology and serology in idiopathic inflammatory myopathy (IIM) classification, has an evolving role. Our study aims to define thigh muscle MRI involvement in IMNM and DM by direct comparison.<h4>Methods</h4>This single-center, retrospective, cross-sectional study included 25 participants, who met IIM classification criteria (14 IMNM, 11 DM) and had available thigh MRI. Clinical and paraclinical data were available and reviewed. 11 muscles were graded for edema on MRI using a semi-quantitative scale (0: normal, 1: <30% of muscle involvement, 2: 31-75","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-02T03:05:01.571Z","creation":"2025-07-02T03:05:01.571Z"},"accession":"S-EPMC12010673","cross_references":{"pubmed":["40259367"],"doi":["10.1186/s41927-025-00500-3"]}}