biostudies-literatureUnknown13Chen J<h4>Background</h4>Whether occult zonulopathy contributes to the development of acute primary angle closure (APAC) remains elusive. This study aimed to determine the association between occult zonulopathy detected during cataract surgery and APAC and to investigate the biometric characteristics of APAC patients with or without occult zonulopathy.<h4>Methods</h4>Retrospective case-control study. A total of 27 Chinese unilateral APAC subjects and 132 control subjects with comprehensive ophthalmic examinations were recruited. Occult zonulopathy was identified with the intraoperative signs during cataract surgery. The proportion of occult zonulopathy was compared between the APAC and control groups. A multivariate logistic analysis was conducted to determine the association between occult zonuPeerJe19330https://www.ebi.ac.uk/biostudies/studies/S-EPMC12010992biostudies-literatureOccult zonulopathy detected during cataract surgery in patients with acute primary angle closure: a retrospective study.PMC12010992Yuan XLHuang YChen JZhang XHuang XDuan XfalseOccult zonulopathy detected during cataract surgery in patients with acute primary angle closure: a retrospective study.<h4>Background</h4>Whether occult zonulopathy contributes to the development of acute primary angle closure (APAC) remains elusive. This study aimed to determine the association between occult zonulopathy detected during cataract surgery and APAC and to investigate the biometric characteristics of APAC patients with or without occult zonulopathy.<h4>Methods</h4>Retrospective case-control study. A total of 27 Chinese unilateral APAC subjects and 132 control subjects with comprehensive ophthalmic examinations were recruited. Occult zonulopathy was identified with the intraoperative signs during cataract surgery. The proportion of occult zonulopathy was compared between the APAC and control groups. A multivariate logistic analysis was conducted to determine the association between occult zonu2025-01-01T00:00:00Z20252025-07-07T03:09:58.478Z2025-07-07T03:09:58.478ZS-EPMC120109924026019310.7717/peerj.19330