{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao Y"],"funding":["Chengde Medical University Discipline Construction Funds, Chengde Science and Technology Bureau","the Cultivating Programme Plan for Clinical Excellent Talent of Hebei in 2023","Research Start-up Fund for High-level Talents of Chengde Medical University"],"pagination":["13673"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12012147"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["TRIM56 plays a role in tumor development through the ubiquitination of several key substrate molecules. However, its relationship with tumor prognosis and immune infiltration remains unclear. The expression and localization of TRIM56 were analyzed from TCGA_GTEx, TCGA and HPA database. The effects of TRIM56 on the proliferation and migration of lung cancer cells A549 were evaluated by CCK-8 and wound healing assays. Correlations between TRIM56 expression and survival in patients were analyzed using the Kaplan-Meier Plotter and a nomogram model. Additionally, the relationship between TRIM56 and immune cell infiltration in tumors was explored via TIMER 2.0. Functional interactions and associated proteins of TRIM56 were examined using GEPIA 2.0 and the STING database. The signaling pathways i"],"journal":["Scientific reports"],"pubmed_title":["Comprehensive analysis of TRIM56's prognostic value and immune infiltration in Pan-Cancer."],"pmcid":["PMC12012147"],"funding_grant_id":["202204A164","ZF2023249","202409"],"pubmed_authors":["Liu Y","Kong L","Zhai Y","Ji H","Wang C","Cao Y","Zhao W","Wang J","Hou W","He P"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of TRIM56's prognostic value and immune infiltration in Pan-Cancer.","description":"TRIM56 plays a role in tumor development through the ubiquitination of several key substrate molecules. However, its relationship with tumor prognosis and immune infiltration remains unclear. The expression and localization of TRIM56 were analyzed from TCGA_GTEx, TCGA and HPA database. The effects of TRIM56 on the proliferation and migration of lung cancer cells A549 were evaluated by CCK-8 and wound healing assays. Correlations between TRIM56 expression and survival in patients were analyzed using the Kaplan-Meier Plotter and a nomogram model. Additionally, the relationship between TRIM56 and immune cell infiltration in tumors was explored via TIMER 2.0. Functional interactions and associated proteins of TRIM56 were examined using GEPIA 2.0 and the STING database. The signaling pathways i","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-07T03:10:07.986Z","creation":"2025-07-07T03:10:07.986Z"},"accession":"S-EPMC12012147","cross_references":{"pubmed":["40258986"],"doi":["10.1038/s41598-025-97856-w"]}}