biostudies-literatureMundt JMNCATS NIH HHSNorthwestern University Center for Circadian and Sleep MedicineNHLBI NIH HHSNINDS NIH HHSe14384https://www.ebi.ac.uk/biostudies/studies/S-EPMC12012161biostudies-literatureUnknown34(3)Nightmares are a common symptom in narcolepsy that has not been targeted in prior clinical trials. This study investigated the efficacy of Cognitive Behavioural Therapy for Nightmares (CBT-N), adapted for narcolepsy, in a small group of adults. Given the high prevalence of lucid dreaming in narcolepsy, we added a promising adjuvant component, targeted lucidity reactivation (TLR), a procedure designed to enhance lucid dreaming and dream control. Using a multiple baseline single-case experimental design, adults with narcolepsy and frequent nightmares (≥3/week, N = 6) were randomised to a 2 or 4 week baseline and received seven treatment sessions (CBT-N or CBT-N + TLR). Across the groups, there was a large effect size (between-case standardised mean difference [BC-SMD] = -0.97, 95% CI -1.79 tJournal of sleep researchTreating narcolepsy-related nightmares with cognitive behavioural therapy and targeted lucidity reactivation: A pilot study.PMC12012161n/aUL1 TR001422T32 NS047987T32 HL007909Byskosh NMaski KCasiello-Robbins CMundt JMKonkoly KRMorris DJMallett RPruiksma KETorres-Platas SGPaller KANadorff MRFranklin RCKaranth SfalseTreating narcolepsy-related nightmares with cognitive behavioural therapy and targeted lucidity reactivation: A pilot study.Nightmares are a common symptom in narcolepsy that has not been targeted in prior clinical trials. This study investigated the efficacy of Cognitive Behavioural Therapy for Nightmares (CBT-N), adapted for narcolepsy, in a small group of adults. Given the high prevalence of lucid dreaming in narcolepsy, we added a promising adjuvant component, targeted lucidity reactivation (TLR), a procedure designed to enhance lucid dreaming and dream control. Using a multiple baseline single-case experimental design, adults with narcolepsy and frequent nightmares (≥3/week, N = 6) were randomised to a 2 or 4 week baseline and received seven treatment sessions (CBT-N or CBT-N + TLR). Across the groups, there was a large effect size (between-case standardised mean difference [BC-SMD] = -0.97, 95% CI -1.79 t2025-01-01T00:00:00Z2025 Jun2026-06-01T14:49:42.174Z2026-04-08T13:33:41.884ZS-EPMC120121613943813110.1111/jsr.14384