{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Munoz-Martin N"],"funding":["EMBO","'la Caixa' Foundation Severo Ochoa PhD Fellowship","Comunidad de Madrid","Ministerio de Ciencia e Innovación","CNIC","Spanish","Ministerio de Ciencia e Innovación and the Pro CNIC Foundation","‘la Caixa’ Foundation Severo Ochoa PhD Fellowship","the Ministry of Education, Youth and Sports","of the Czech Republic","Czech Science Foundation","European Commission H2020 Program"],"pagination":["311-323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12012448"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(2)"],"pubmed_abstract":["Aims
The cardiac conduction system (CCS) is progressively specified during development by interactions among a discrete number of transcription factors (TFs) that ensure its proper patterning and the emergence of its functional properties. Meis genes encode homeodomain TFs with multiple roles in mammalian development. In humans, Meis genes associate with congenital cardiac malformations and alterations of cardiac electrical activity; however, the basis for these alterations has not been established. Here, we studied the role of Meis TFs in cardiomyocyte development and function during mouse development and adult life.Methods and results
We studied Meis1 and Meis2 conditional deletion mouse models that allowed cardiomyocyte-specific elimination of Meis function during develo"],"journal":["Cardiovascular research"],"pubmed_title":["Meis transcription factors regulate cardiac conduction system development and adult function."],"pmcid":["PMC12012448"],"funding_grant_id":["SC1-BHC-07-2019","22-05271S","P2022/BMD-7245","PID2019-109329RB-I00","CEX2020-001041-S","LCF/BQ/DR19/11740029","100010434","7667","PGC2018-096486-B-I00","PID2022-140058NB-C31","207029","18-03461S"],"pubmed_authors":["Esteban I","Torres M","Diaz-Diaz C","Winkelmann J","Sedmera D","Cadenas V","Ludwig A","Simon-Chica A","Schormair B","Temino S","Olejnickova V","Munoz-Martin N","Filgueiras-Rama D"],"additional_accession":[]},"is_claimable":false,"name":"Meis transcription factors regulate cardiac conduction system development and adult function.","description":"Aims
The cardiac conduction system (CCS) is progressively specified during development by interactions among a discrete number of transcription factors (TFs) that ensure its proper patterning and the emergence of its functional properties. Meis genes encode homeodomain TFs with multiple roles in mammalian development. In humans, Meis genes associate with congenital cardiac malformations and alterations of cardiac electrical activity; however, the basis for these alterations has not been established. Here, we studied the role of Meis TFs in cardiomyocyte development and function during mouse development and adult life.Methods and results
We studied Meis1 and Meis2 conditional deletion mouse models that allowed cardiomyocyte-specific elimination of Meis function during develo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-04-14T03:21:09.244Z","creation":"2025-07-03T03:04:43.861Z"},"accession":"S-EPMC12012448","cross_references":{"pubmed":["39691060"],"doi":["10.1093/cvr/cvae258"]}}