{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(4)"],"submitter":["Pan C"],"pubmed_abstract":["The interaction between microbiota and muscle by the rumen-muscle axis and its impact on sheep meat flavor has received little attention. This study selected Xizang sheep under summer and autumn grazing conditions as models for different rumen bacteria and intramuscular fat (IMF) to attempt to address the current research gap. Specifically, the deposition characteristics of IMF and the expression of lipid metabolism genes in Xizang sheep were determined; 16S rDNA sequencing technology and gas chromatography were used to study the rumen microbiota and its metabolic products, short-chain fatty acids (SCFAs); RNA sequencing was used to identify the transcriptome of the rumen epithelium. Based on the above results, we proposed the hypothesis that the flavor of Xizang sheep meat is regulated by"],"journal":["mSystems"],"pagination":["e0155724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12013263"],"repository":["biostudies-literature"],"pubmed_title":["Rumen microbiota regulates IMF deposition in Xizang sheep by activating the <i>PPARγ</i> transcription factor: a rumen-muscle axis perspective."],"pmcid":["PMC12013263"],"pubmed_authors":["Li H","Pan J","Pan C","Zhang Z","Jinmei J","Guan F","Baijiu Z","Song T","Zhao W","Zhaxi Y","Baima S","Yixi Q"],"additional_accession":[]},"is_claimable":false,"name":"Rumen microbiota regulates IMF deposition in Xizang sheep by activating the <i>PPARγ</i> transcription factor: a rumen-muscle axis perspective.","description":"The interaction between microbiota and muscle by the rumen-muscle axis and its impact on sheep meat flavor has received little attention. This study selected Xizang sheep under summer and autumn grazing conditions as models for different rumen bacteria and intramuscular fat (IMF) to attempt to address the current research gap. Specifically, the deposition characteristics of IMF and the expression of lipid metabolism genes in Xizang sheep were determined; 16S rDNA sequencing technology and gas chromatography were used to study the rumen microbiota and its metabolic products, short-chain fatty acids (SCFAs); RNA sequencing was used to identify the transcriptome of the rumen epithelium. Based on the above results, we proposed the hypothesis that the flavor of Xizang sheep meat is regulated by","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-15T11:05:20.902Z","creation":"2025-07-03T03:05:20.256Z"},"accession":"S-EPMC12013263","cross_references":{"pubmed":["40152602"],"doi":["10.1128/msystems.01557-24"]}}