{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["115"],"submitter":["Sasamoto N"],"pubmed_abstract":["<h4>Background</h4>Endometriosis is a chronic inflammatory condition characterised by pain and infertility. We conducted a prospective study to elucidate the pathophysiological mechanisms underlying endometriosis development.<h4>Methods</h4>We examined the association between 1305 proteins measured by SomaScan proteomics and risk of endometriosis diagnosis in prospectively collected plasma from 200 laparoscopically-confirmed endometriosis cases and 200 risk-set sampling matched controls within the Nurses' Health Study II (NHSII) cohort. Using conditional logistic regression, we calculated odds ratios (OR) and 95% confidence intervals (CI) per one standard deviation increase in protein levels and area under the curve (AUC) to assess the multi-protein model in discriminating cases from contr"],"journal":["EBioMedicine"],"pagination":["105688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12013659"],"repository":["biostudies-literature"],"pubmed_title":["Prospective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses' Health Study II."],"pmcid":["PMC12013659"],"pubmed_authors":["Vitonis AF","Missmer SA","Sasamoto N","Aziz M","Shafrir AL","Terry KL","Libermann TA","Ngo LH","Dillon ST"],"additional_accession":[]},"is_claimable":false,"name":"Prospective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses' Health Study II.","description":"<h4>Background</h4>Endometriosis is a chronic inflammatory condition characterised by pain and infertility. We conducted a prospective study to elucidate the pathophysiological mechanisms underlying endometriosis development.<h4>Methods</h4>We examined the association between 1305 proteins measured by SomaScan proteomics and risk of endometriosis diagnosis in prospectively collected plasma from 200 laparoscopically-confirmed endometriosis cases and 200 risk-set sampling matched controls within the Nurses' Health Study II (NHSII) cohort. Using conditional logistic regression, we calculated odds ratios (OR) and 95% confidence intervals (CI) per one standard deviation increase in protein levels and area under the curve (AUC) to assess the multi-protein model in discriminating cases from contr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-01T03:05:08.487Z","creation":"2025-07-01T03:05:08.487Z"},"accession":"S-EPMC12013659","cross_references":{"pubmed":["40215752"],"doi":["10.1016/j.ebiom.2025.105688"]}}