biostudies-literatureUnknown115Sasamoto N<h4>Background</h4>Endometriosis is a chronic inflammatory condition characterised by pain and infertility. We conducted a prospective study to elucidate the pathophysiological mechanisms underlying endometriosis development.<h4>Methods</h4>We examined the association between 1305 proteins measured by SomaScan proteomics and risk of endometriosis diagnosis in prospectively collected plasma from 200 laparoscopically-confirmed endometriosis cases and 200 risk-set sampling matched controls within the Nurses' Health Study II (NHSII) cohort. Using conditional logistic regression, we calculated odds ratios (OR) and 95% confidence intervals (CI) per one standard deviation increase in protein levels and area under the curve (AUC) to assess the multi-protein model in discriminating cases from contrEBioMedicine105688https://www.ebi.ac.uk/biostudies/studies/S-EPMC12013659biostudies-literatureProspective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses' Health Study II.PMC12013659Vitonis AFMissmer SASasamoto NAziz MShafrir ALTerry KLLibermann TANgo LHDillon STfalseProspective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses' Health Study II.<h4>Background</h4>Endometriosis is a chronic inflammatory condition characterised by pain and infertility. We conducted a prospective study to elucidate the pathophysiological mechanisms underlying endometriosis development.<h4>Methods</h4>We examined the association between 1305 proteins measured by SomaScan proteomics and risk of endometriosis diagnosis in prospectively collected plasma from 200 laparoscopically-confirmed endometriosis cases and 200 risk-set sampling matched controls within the Nurses' Health Study II (NHSII) cohort. Using conditional logistic regression, we calculated odds ratios (OR) and 95% confidence intervals (CI) per one standard deviation increase in protein levels and area under the curve (AUC) to assess the multi-protein model in discriminating cases from contr2025-01-01T00:00:00Z2025 Apr2025-07-01T03:05:08.487Z2025-07-01T03:05:08.487ZS-EPMC120136594021575210.1016/j.ebiom.2025.105688