{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(2)"],"submitter":["Debatisse J"],"pubmed_abstract":["Microvascular dysfunction and no-reflow are considered a major cause of secondary damage despite revascularization in acute ischemic stroke (AIS), ultimately affecting patient outcomes. We used quantitative PET-MRI imaging to characterize early microvascular damages in a preclinical non-human primate model mimicking endovascular mechanical thrombectomy (EVT). During occlusion, PET perfusion and MRI diffusion were used to measure ischemic and lesion core volumes respectively. Following revascularization, multiparametric PET-MRI included perfusion, diffusion, blood-brain barrier (BBB) permeability MRI, and <sup>15</sup>O-oxygen metabolism PET. Lesion growth on MRI was evaluated at one week, and the neurological score was assessed daily; a poor outcome was defined as a score>6 (0-normal, 60-d"],"journal":["Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics"],"pagination":["e00529"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12014402"],"repository":["biostudies-literature"],"pubmed_title":["Quantitative imaging outperforms No-reflow in predicting functional outcomes in a translational stroke model."],"pmcid":["PMC12014402"],"pubmed_authors":["Boutelier T","Leon C","Wiart M","Cho TH","Eker OF","Lancelot S","Wateau O","Lux F","Nighoghossian N","Canet-Soulas E","Chalet L","Mechtouff L","Becker G","Costes N","Merida I","Langlois JB","Debatisse J"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative imaging outperforms No-reflow in predicting functional outcomes in a translational stroke model.","description":"Microvascular dysfunction and no-reflow are considered a major cause of secondary damage despite revascularization in acute ischemic stroke (AIS), ultimately affecting patient outcomes. We used quantitative PET-MRI imaging to characterize early microvascular damages in a preclinical non-human primate model mimicking endovascular mechanical thrombectomy (EVT). During occlusion, PET perfusion and MRI diffusion were used to measure ischemic and lesion core volumes respectively. Following revascularization, multiparametric PET-MRI included perfusion, diffusion, blood-brain barrier (BBB) permeability MRI, and <sup>15</sup>O-oxygen metabolism PET. Lesion growth on MRI was evaluated at one week, and the neurological score was assessed daily; a poor outcome was defined as a score>6 (0-normal, 60-d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-07T03:08:56.543Z","creation":"2025-07-07T03:08:56.543Z"},"accession":"S-EPMC12014402","cross_references":{"pubmed":["39893086"],"doi":["10.1016/j.neurot.2025.e00529"]}}