biostudies-literatureUnknown22(2)Debatisse JMicrovascular dysfunction and no-reflow are considered a major cause of secondary damage despite revascularization in acute ischemic stroke (AIS), ultimately affecting patient outcomes. We used quantitative PET-MRI imaging to characterize early microvascular damages in a preclinical non-human primate model mimicking endovascular mechanical thrombectomy (EVT). During occlusion, PET perfusion and MRI diffusion were used to measure ischemic and lesion core volumes respectively. Following revascularization, multiparametric PET-MRI included perfusion, diffusion, blood-brain barrier (BBB) permeability MRI, and ¹⁵O-oxygen metabolism PET. Lesion growth on MRI was evaluated at one week, and the neurological score was assessed daily; a poor outcome was defined as a score>6 (0-normal, 60-dNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticse00529https://www.ebi.ac.uk/biostudies/studies/S-EPMC12014402biostudies-literatureQuantitative imaging outperforms No-reflow in predicting functional outcomes in a translational stroke model.PMC12014402Boutelier TLeon CWiart MCho THEker OFLancelot SWateau OLux FNighoghossian NCanet-Soulas EChalet LMechtouff LBecker GCostes NMerida ILanglois JBDebatisse JfalseQuantitative imaging outperforms No-reflow in predicting functional outcomes in a translational stroke model.Microvascular dysfunction and no-reflow are considered a major cause of secondary damage despite revascularization in acute ischemic stroke (AIS), ultimately affecting patient outcomes. We used quantitative PET-MRI imaging to characterize early microvascular damages in a preclinical non-human primate model mimicking endovascular mechanical thrombectomy (EVT). During occlusion, PET perfusion and MRI diffusion were used to measure ischemic and lesion core volumes respectively. Following revascularization, multiparametric PET-MRI included perfusion, diffusion, blood-brain barrier (BBB) permeability MRI, and ¹⁵O-oxygen metabolism PET. Lesion growth on MRI was evaluated at one week, and the neurological score was assessed daily; a poor outcome was defined as a score>6 (0-normal, 60-d2025-01-01T00:00:00Z2025 Mar2025-07-07T03:08:56.543Z2025-07-07T03:08:56.543ZS-EPMC120144023989308610.1016/j.neurot.2025.e00529