{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Munhoz DD"],"pubmed_abstract":["<h4>Introduction</h4>Uveitis accounts for up to 25% of global legal blindness and involves intraocular inflammation, classifed as infectious or non-infectious. Its complex pathophysiology includes dysregulated cytokines, particularly interferons (IFNs). However, the global signature of type I, II, and III interferon-regulated genes (Interferome) remains largely uncharacterized in uveitis.<h4>Methods</h4>In this study, we conducted an integrative systems biology analysis of blood transcriptome data from 169 non-infectious uveitis patients (56 isolated uveitis, 113 systemic disease-associated uveitis) and 82 healthy controls.<h4>Results</h4>Modular co-expression analysis identified distinct cytokine signaling networks, emphasizing interleukin and interferon pathways. A meta-analysis revealed"],"journal":["Frontiers in immunology"],"pagination":["1509805"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12014655"],"repository":["biostudies-literature"],"pubmed_title":["Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis."],"pmcid":["PMC12014655"],"pubmed_authors":["Fonseca DLM","Nakaya HI","Dias HD","Schimke LF","Jurisica I","Ochs HD","Filgueiras IS","Rizzo LV","Munhoz DD","Cabral-Marques O"],"additional_accession":[]},"is_claimable":false,"name":"Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis.","description":"<h4>Introduction</h4>Uveitis accounts for up to 25% of global legal blindness and involves intraocular inflammation, classifed as infectious or non-infectious. Its complex pathophysiology includes dysregulated cytokines, particularly interferons (IFNs). However, the global signature of type I, II, and III interferon-regulated genes (Interferome) remains largely uncharacterized in uveitis.<h4>Methods</h4>In this study, we conducted an integrative systems biology analysis of blood transcriptome data from 169 non-infectious uveitis patients (56 isolated uveitis, 113 systemic disease-associated uveitis) and 82 healthy controls.<h4>Results</h4>Modular co-expression analysis identified distinct cytokine signaling networks, emphasizing interleukin and interferon pathways. A meta-analysis revealed","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-10T03:08:57.927Z","creation":"2025-07-10T03:08:57.927Z"},"accession":"S-EPMC12014655","cross_references":{"pubmed":["40270958"],"doi":["10.3389/fimmu.2025.1509805"]}}