biostudies-literatureUnknown16Munhoz DD<h4>Introduction</h4>Uveitis accounts for up to 25% of global legal blindness and involves intraocular inflammation, classifed as infectious or non-infectious. Its complex pathophysiology includes dysregulated cytokines, particularly interferons (IFNs). However, the global signature of type I, II, and III interferon-regulated genes (Interferome) remains largely uncharacterized in uveitis.<h4>Methods</h4>In this study, we conducted an integrative systems biology analysis of blood transcriptome data from 169 non-infectious uveitis patients (56 isolated uveitis, 113 systemic disease-associated uveitis) and 82 healthy controls.<h4>Results</h4>Modular co-expression analysis identified distinct cytokine signaling networks, emphasizing interleukin and interferon pathways. A meta-analysis revealedFrontiers in immunology1509805https://www.ebi.ac.uk/biostudies/studies/S-EPMC12014655biostudies-literatureIntegrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis.PMC12014655Fonseca DLMNakaya HIDias HDSchimke LFJurisica IOchs HDFilgueiras ISRizzo LVMunhoz DDCabral-Marques OfalseIntegrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis.<h4>Introduction</h4>Uveitis accounts for up to 25% of global legal blindness and involves intraocular inflammation, classifed as infectious or non-infectious. Its complex pathophysiology includes dysregulated cytokines, particularly interferons (IFNs). However, the global signature of type I, II, and III interferon-regulated genes (Interferome) remains largely uncharacterized in uveitis.<h4>Methods</h4>In this study, we conducted an integrative systems biology analysis of blood transcriptome data from 169 non-infectious uveitis patients (56 isolated uveitis, 113 systemic disease-associated uveitis) and 82 healthy controls.<h4>Results</h4>Modular co-expression analysis identified distinct cytokine signaling networks, emphasizing interleukin and interferon pathways. A meta-analysis revealed2025-01-01T00:00:00Z20252025-07-10T03:08:57.927Z2025-07-10T03:08:57.927ZS-EPMC120146554027095810.3389/fimmu.2025.1509805