biostudies-literatureUnknown16Cheng X<h4>Background</h4>Diabetes is one common clinical symptoms of metabolic disorders. The peel of <i>Zea mays</i> L. is a folk remedy for diabetes that has not been thoroughly studied. The effects and mechanisms on diabetes complicated glucose and lipid metabolism disorders are still unknown now.<h4>Purpose</h4>The research is intended to elucidate the constituent of phenylpropanoid enriched of <i>Zea mays</i> L. (YMP), and investigate the treatment and mechanism on amending glucose and lipid metabolism disorders.<h4>Methods</h4>The constituents of YMP were systematacially identified by HPLC-Q-TOF-MS/MS and NMR. To assess the effects of varying YMP doses, diabetic mice induced by streptozotocin and a high-fat diet were divided into groups. Targeted serum metabolomics investigations were condFrontiers in pharmacology1551713https://www.ebi.ac.uk/biostudies/studies/S-EPMC12014729biostudies-literatureTargeted metabolomics unravels the mechanism by phenylpropanoid-rich of the peel of <i>Zea mays</i> L. ameliorates metabolic disorders in diabetic mice through gut microbiota modulation.PMC12014729Yang YLing BHe YWang AHe JChen GCheng XfalseTargeted metabolomics unravels the mechanism by phenylpropanoid-rich of the peel of <i>Zea mays</i> L. ameliorates metabolic disorders in diabetic mice through gut microbiota modulation.<h4>Background</h4>Diabetes is one common clinical symptoms of metabolic disorders. The peel of <i>Zea mays</i> L. is a folk remedy for diabetes that has not been thoroughly studied. The effects and mechanisms on diabetes complicated glucose and lipid metabolism disorders are still unknown now.<h4>Purpose</h4>The research is intended to elucidate the constituent of phenylpropanoid enriched of <i>Zea mays</i> L. (YMP), and investigate the treatment and mechanism on amending glucose and lipid metabolism disorders.<h4>Methods</h4>The constituents of YMP were systematacially identified by HPLC-Q-TOF-MS/MS and NMR. To assess the effects of varying YMP doses, diabetic mice induced by streptozotocin and a high-fat diet were divided into groups. Targeted serum metabolomics investigations were cond2025-01-01T00:00:00Z20252025-07-02T03:04:51.57Z2025-07-02T03:04:51.57ZS-EPMC120147294027105810.3389/fphar.2025.1551713