{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Poole JA"],"funding":["BLRD VA","NIOSH CDC HHS","NIGMS NIH HHS","CSRD VA"],"pagination":["1557583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12014730"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["<h4>Background</h4>Lung disease is the most overrepresented cause of death in rheumatoid arthritis (RA). Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung disease with a combination of airborne exposures and collagen-induced arthritis (CIA), a model that recapitulates features of RA-associated interstitial lung disease (RA-ILD). As patients with RA-ILD demonstrate unique circulating monocyte subpopulations, this study aims to characterize lung infiltrating monocytes/macrophages in a mouse model of RA-ILD and determine whether reducing these cells mitigates the development of lung disease.<h4>Methods</h4>Autoimmune-prone DBA/1J mice received intranasal inhalation of lipopolysaccharide (LPS) daily for up to 5 weeks and CIA induction. Expe"],"journal":["Frontiers in immunology"],"pubmed_title":["Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis."],"pmcid":["PMC12014730"],"funding_grant_id":["I01 BX005886","R01 OH012045","IK6 BX003781","I01 BX004660","IS1 BX004790","I01 BX003635","U54 GM115458","IK6 BX005962","IK2 CX002203","U54 OH010162"],"pubmed_authors":["Duryee MJ","Nelson AJ","Poole JA","Wyatt TA","England BR","Mikuls TR","Thiele GM","Schwab A","Schanze OW","Gleason A"],"additional_accession":[]},"is_claimable":false,"name":"Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis.","description":"<h4>Background</h4>Lung disease is the most overrepresented cause of death in rheumatoid arthritis (RA). Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung disease with a combination of airborne exposures and collagen-induced arthritis (CIA), a model that recapitulates features of RA-associated interstitial lung disease (RA-ILD). As patients with RA-ILD demonstrate unique circulating monocyte subpopulations, this study aims to characterize lung infiltrating monocytes/macrophages in a mouse model of RA-ILD and determine whether reducing these cells mitigates the development of lung disease.<h4>Methods</h4>Autoimmune-prone DBA/1J mice received intranasal inhalation of lipopolysaccharide (LPS) daily for up to 5 weeks and CIA induction. Expe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-22T03:12:23.941Z","creation":"2025-07-02T03:04:50.439Z"},"accession":"S-EPMC12014730","cross_references":{"pubmed":["40270956"],"doi":["10.3389/fimmu.2025.1557583"]}}