biostudies-literaturePoole JABLRD VANIOSH CDC HHSNIGMS NIH HHSCSRD VA1557583https://www.ebi.ac.uk/biostudies/studies/S-EPMC12014730biostudies-literatureUnknown16<h4>Background</h4>Lung disease is the most overrepresented cause of death in rheumatoid arthritis (RA). Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung disease with a combination of airborne exposures and collagen-induced arthritis (CIA), a model that recapitulates features of RA-associated interstitial lung disease (RA-ILD). As patients with RA-ILD demonstrate unique circulating monocyte subpopulations, this study aims to characterize lung infiltrating monocytes/macrophages in a mouse model of RA-ILD and determine whether reducing these cells mitigates the development of lung disease.<h4>Methods</h4>Autoimmune-prone DBA/1J mice received intranasal inhalation of lipopolysaccharide (LPS) daily for up to 5 weeks and CIA induction. ExpeFrontiers in immunologyLung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis.PMC12014730I01 BX005886R01 OH012045IK6 BX003781I01 BX004660IS1 BX004790I01 BX003635U54 GM115458IK6 BX005962IK2 CX002203U54 OH010162Duryee MJNelson AJPoole JAWyatt TAEngland BRMikuls TRThiele GMSchwab ASchanze OWGleason AfalseLung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis.<h4>Background</h4>Lung disease is the most overrepresented cause of death in rheumatoid arthritis (RA). Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung disease with a combination of airborne exposures and collagen-induced arthritis (CIA), a model that recapitulates features of RA-associated interstitial lung disease (RA-ILD). As patients with RA-ILD demonstrate unique circulating monocyte subpopulations, this study aims to characterize lung infiltrating monocytes/macrophages in a mouse model of RA-ILD and determine whether reducing these cells mitigates the development of lung disease.<h4>Methods</h4>Autoimmune-prone DBA/1J mice received intranasal inhalation of lipopolysaccharide (LPS) daily for up to 5 weeks and CIA induction. Expe2025-01-01T00:00:00Z20252026-05-22T03:12:23.941Z2025-07-02T03:04:50.439ZS-EPMC120147304027095610.3389/fimmu.2025.1557583