{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rabl M"],"funding":["Lumosity","Alzheimer’s Therapeutic Research Institute, University of Southern California","NIA NIH HHS","Cogstate","Universität Zürich","Meso Scale Diagnostics","IXICO","GE Healthcare","Canadian Institutes of Health Research","Merck","Eli Lilly and Company","CereSpir, Inc.","Transition Therapeutics","Clinical Center","Janssen Pharmaceutica","Eisai Incorporated","Novartis Pharmaceuticals Corporation","Takeda Pharmaceutical Company","Foundation for the National Institutes of Health","Northern California Institute for Research and Education","Laboratory for Neuro Imaging, University of Southern California","BioClinica","Araclon Biotech","Servier","Alzheimer’s Drug Discovery Foundation","Defense Health Agency","Bristol-Myers Squibb","Stiftung Synapsis - Alzheimer Forschung Schweiz AFS","Pfizer","Neurotrack Technologies","AbbVie","Lundbeck Foundation","Piramal Imaging","Johnson and Johnson Pharmaceutical Research and Development","NeuroRx Research","Alzheimer’s Association","Swiss National Science Foundation","Genentech","Fujirebio US","Biogen","Euroimmun","Elan Pharmaceuticals Inc."],"pagination":["370-382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12015082"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["96(4)"],"pubmed_abstract":["<h4>Background and objectives</h4>Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.<h4>Methods</h4>A panel of 190 plasma proteins was quantified using Luminex xMAP in the Alzheimer's Disease Neuroimaging Initiative cohort. NPS and cognitive performance were assessed at baseline and after 1 and 2 years. Logistic regression, receiver operating characteristic analysis and cross-validation were used to address the relations of interest.<h4>Results</h4>A total of 507 participants with mild cognitive i"],"journal":["Journal of neurology, neurosurgery, and psychiatry"],"pubmed_title":["Neuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics."],"pmcid":["PMC12015082"],"funding_grant_id":["N/A","2017-PI01","320030","141179","Filling the Gap","320030_141179","U01 AG024904","P30 AG066514","P30 AG066518","W81XWH-12-2-0012","320030_204886"],"pubmed_authors":["Schulze E","Haviari A","Koepp RA","Ayers K","Brewer J","Palou M","Ayres M","Rosen HJ","Yurko E","Sacrey D","Riddle M","Montine T","Ramirez J","Manning S","Russell H","Blanchard K","Wint D","Matoush L","DeStefano S","Reeder S","Moore-Weiss J","Bailey R","Levey A","Wu CK","Fletcher E","Lee EB","Munic D","White M","Yu M","Schwarz C","Pietras A","May J","Ton A","White S","Ashe 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cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.","description":"<h4>Background and objectives</h4>Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.<h4>Methods</h4>A panel of 190 plasma proteins was quantified using Luminex xMAP in the Alzheimer's Disease Neuroimaging Initiative cohort. NPS and cognitive performance were assessed at baseline and after 1 and 2 years. Logistic regression, receiver operating characteristic analysis and cross-validation were used to address the relations of interest.<h4>Results</h4>A total of 507 participants with mild cognitive i","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-02T00:03:09.517Z","creation":"2025-07-03T03:05:09.014Z"},"accession":"S-EPMC12015082","cross_references":{"pubmed":["39288961"],"doi":["10.1136/jnnp-2024-333819"]}}