biostudies-literatureRabl MLumosityAlzheimer’s Therapeutic Research Institute, University of Southern CaliforniaNIA NIH HHSCogstateUniversität ZürichMeso Scale DiagnosticsIXICOGE HealthcareCanadian Institutes of Health ResearchMerckEli Lilly and CompanyCereSpir, Inc.Transition TherapeuticsClinical CenterJanssen PharmaceuticaEisai IncorporatedNovartis Pharmaceuticals CorporationTakeda Pharmaceutical CompanyFoundation for the National Institutes of HealthNorthern California Institute for Research and EducationLaboratory for Neuro Imaging, University of Southern CaliforniaBioClinicaAraclon BiotechServierAlzheimer’s Drug Discovery FoundationDefense Health AgencyBristol-Myers SquibbStiftung Synapsis - Alzheimer Forschung Schweiz AFSPfizerNeurotrack TechnologiesAbbVieLundbeck FoundationPiramal ImagingJohnson and Johnson Pharmaceutical Research and DevelopmentNeuroRx ResearchAlzheimer’s AssociationSwiss National Science FoundationGenentechFujirebio USBiogenEuroimmunElan Pharmaceuticals Inc.370-382https://www.ebi.ac.uk/biostudies/studies/S-EPMC12015082biostudies-literatureUnknown96(4)<h4>Background and objectives</h4>Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.<h4>Methods</h4>A panel of 190 plasma proteins was quantified using Luminex xMAP in the Alzheimer's Disease Neuroimaging Initiative cohort. NPS and cognitive performance were assessed at baseline and after 1 and 2 years. Logistic regression, receiver operating characteristic analysis and cross-validation were used to address the relations of interest.<h4>Results</h4>A total of 507 participants with mild cognitive iJournal of neurology, neurosurgery, and psychiatryNeuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.PMC12015082N/A2017-PI01320030141179Filling the Gap320030_141179U01 AG024904P30 AG066514P30 AG066518W81XWH-12-2-0012320030_204886Schulze EHaviari AKoepp RAAyers KBrewer JPalou MAyres MRosen HJYurko ESacrey DRiddle MMontine TRamirez JManning SRussell HBlanchard KWint DMatoush LDeStefano SReeder SMoore-Weiss JBailey RLevey AWu CKFletcher ELee EBMunic DWhite MYu MSchwarz CPietras AMay JTon AWhite SAshe LCornell GVillar MThao MMossa DFaircloth JScanlan MFerng NSantiago SGallagher LPetrocca EHosein CLowery SDevis YVincent SNyborg GBecerra MZimmerman CLittle EFerman DJo TApostolova LGLah JBriglall VD'Ambrosio SSchoolcraft LLandau SFockler JHaddad LRaynes-Goldfinger DHenson RSaunders AKahulugan QMalia AChen SBinder SGoldfarb DRao LHoover BNelson GWagner BSharma SPomara VElmalik WPomara NHergesheimer LMalakauskas SChen DLukose LAlosco MFleisher AMartinez NNho KSadowski MSullivan SJohnson KOrdor DImhansiemhonehi MJohnson MJohnson NSwarm RJohnson SMartinez TStipanovich AMartinez WKertesz AMarolt ARafii MPerez GMunoz CArnold AJagust WPhillips ESwitzer PScharre DWAnderson KCorona MBhan AAnderson BCrawley KMoretz LVemuri PShen LKnaack JRaji CShah RLoPresti BRamamurthy AWan YCallan MTosun-Turgut DMcColl RCheatham ESalazar RFogerty TArthur ADuffy CTong HSalazar JKnaack ABrosch JSmilowitz SBateman JLyons CRufo VLarkin KTrujillo SWalter SZiolkowski JKnopman DZik CMolchan SCairns NJLuu TThomas ABuckholtz NLocke MNunes PThomas LMasterman DCabrera YSantulli RBGagliano NDawson CBaker WPacini NTran AHendrickson KWeiner MSnyder PJSchneider LAmoyaw MBlank KQuinlan LErkkinen MRivera FNewhouse PRivera EKadiri OLyron SIkner GBlack SStapleton KBeckett LZamora ESchumacher MOgrocki PGermano KHernando RCereijo MWenner VKachaturian ZWebster JBates VSlazyk DRichards ARabinovici GPot SRabl MBates CLenio SHarvey DWard CBonacorsi ZFarchi MDas SFairooz MBarger BHarrison WMunie SBergman HJahanshad NTrejo ESpicer KUffelman JGhesani NKhan ASotelo VHenkle SYong MKhan JPresto SKurvach RAssaly MKantarci KBernard MSanborn VOleary KTaylor RStrong JMecca AJames OOkonkwo ITaylor JPierce AHegedus SGutierrez MOkonkwo OPomper MParkins SPopp JMba IWright EYau EFidell ABoeve BBurgos-Rivera GPolson HNudelman KDuara RHales CSano MRojas YTosun DGonzalez JWatkins ALin EGonzalez HFrolov AWinterton SRobison JHendrix HJones FCapote HNeu SDayon LChoudhury PJones DDonnelly LConti CNir TMHolvey BDuncan CKalowsky TEnglish CKreszyn KTalavera SFarrington LBoudreau JBissig DMcKinley ESavage KHill SAshley LBorowski BThompson DQiu WWeisensel TPlace PFarlow MAmaza HHunt RGood SLargent EApuango XAsbach MRobbins LDevereux GWallace BAlbers CAsh SWallace KFranklin ERyan LScott CCombs MRuszkiewicz JChoe MHawk TLuong BMarti BMorris JJackson KFlenniken DBrylska MChao SVillena TJackson JO'Donnell PWatts LAtri AFaber KBurns JThompson PSteinberg EVides BMoss AFalletta JSinn MTallakson MVeronelli DJacobson AClark JWilson SWilson TClark KZhang HIntorcia DHirtreiter JClark CClark ERaja AAmtashar FSArdolino AJin CSilverberg NRudd TAdhikari ABasham KKaye JMontero AFatica PHellegers CHussen KTrost DYeboah SBohlman SJohns JPontone GKilliany RBoegel AOakley MRosario CSilbert LMurali Doraiswamy PDay GVogler BMacnamara HLauture MFelmlee JBonomi RHopkins KBoatwright VDay TWesterhold ECalzavara RMahboubi PSaganis XForoud TMSlaughter MEllison AKelley BPejic JGarrison SZawislak RRuan ARainka MForghanian-Arani ABrown ANunez MHedberg CTroutman ADenis RMorales EStanhope JBarker RMorales JFrascino JShang YBarker WMasurkar ABarcelos NBrooks RGlueck AGoins LLe RGarcia-Camilo GMcGinnis SMonarrez CDemsky CKhera ACorreia SFriedman PMathews DLam BKenowsky SGreeson JDrake EMariotti LNasrallah IDahlgren AStover CMathis NBorrie MRodriguez TThai GNieto ARose HSeshadri SAjtai BMagnuson JRobinson ELam JSalardini ESaito NGrossman HMathewson AHamski MMiller MJLongmire CChertkow HVillemagne VOlgin SGunter JMonserratt LJenkins CGeldmacher DJones MREpperson KOlgin JAcevedo MSanders MHackenmiller BYoung IFigueroa EFigueroa CMiller MSalloway SCepeda SKapadia AVaishnavi SRamanan VPekar JLopez OMejia DTurner KMejia KTurner JRisacher SLBeigi MBurney TTurner RAsthana SMcKinzie SWong JRoss DBerner KMandal PBowser SMiller AWong TBishop JMeacham BNichols KRovere RBerman SJanavs JTaghi-Zada ZAladeen TChen MKOkhravi HHarkins KHarkins JGlittenberg MHolt MForenback DGoddard MKo AGunnoud CAjayi AMcAdams-Ortiz CDavis JCarter DTanase CCarter PReynolds BGreen RCHarte TSwiniarski JTeodoro LMechtler LO'Malley SGarcia LGondrez JMcCorkle ESadowsky CBouchachi SGarcia ADetling SDevine RMyers BLiu LPavlik VBlackburn MNosheny RRowell JPlenge JLapins ASwain ARomero RSaykin AJMagana FGraff-Radford JElmore HGraff-Radford NMintz ADaSilva NAvila YHernandez MAcree AVo KHernandez RMunro CBrowning AHartman EIsip RBandy DMarian TAcothley SHarris GLacy KMez JHelland TCooper HAhmed TMwicigi JEchevarria JKaddurah-Daouk RCordona JHoang IJefferson SPolleys RStewart JSenjem MWiesenauer PDoyon KMasliah EPham SYushkevich PAShaffer EEmborsky ASachdev PPizzola JNwosu AJooma IHasbani MGeesey EStern YSabbagh MBartha RConant CFox TToso CRyan CRyan JGlass MUdodong IKhasnavis SShannon MToga AWWeller JDeCapo MManeval JPorsteinsson APerrin RJSoleimani LSacaza KMitchell MBryant RBottoms JStewart WSingh ENelsen KKaplan ADonahue MMcCoubrey HDooly HFransen ERankin LGabriel GPearlson GDJack CRWarren SGallegos MKwang WWishnia MKippels AMacDonald SBarlow LBasheer NMayo CSingh SKorkoyah AGagnon KBuckler RKorst WEigenberger PLedford PMoncayo EBasadre SFikru SWever KHustead HSaklad AHoughtaling NMandal AGamble BMasellis MPotter ZRangel MKovac DBrennan AMiddleton APotter WVaughn PBrennan EKorecka MRangel ADiaz AStone ABrawman-Mintzer OCarpentier SGrant SSilver RMBray JGrant IAlzheimer’s Disease Neuroimaging InitiativeParand LBenedetto JSchwartz DArcuri DGale SWalker EPaczynski MLogan RKusuran JChiado CLawrence KSmith CSmith AFragale DMarshall GObisesan TDonohue MSheppard FFarshadi MSmith SElayan NThomopoulos SICooper EFenice LTariot PShaw LMChapman LClay TCrawford KLee VMLevesque IHu WKowalski NHamm TWilliams AWilliams CCrawford FPerkins AKarlawish JCarrillo MReyes PDeCarli CHonig LPatel HMahaffey JGama ATaylor-Reinwald LDyck CFrank RReyes CReyes DLynch SHall SHoti IHall TCelmins DSmelser BLynch BPawluczyk SAloszka DPeehler TReade MMalone IDittrich CForero AAyo ORoglaski EWidman ABotha HLee TYBernick CBean RAisen PClanton TColvee HWebb CBoonsiri JPetrella JYork KGuzman VUlysse ACraft HMintzer JO'Connor JChaudhary MAshford MGroves AEvans KGui MCalderon SEvans BBarnes LSeidenberg KPerrin ACarlsson CMMares IZotovic LMasdeu JHeidebrink JBernhardt HMalyarenko DMost ESood AMiller BLLiebsack CKreuger CGlennon KReid RO'Dell RRivera-Mindt MMoghekar AOgwang SErickson CHidalgo ETacey PMoore TAlbert MMattle ARivera-Delpin GYazell MLim JMwaura ISchwartz ESFox NCPatterson KBauerle HDaley ATownley RThal LMartin KKoeppe RCamarro TToth MMoorlach KDurbin KHughes KVasanawala MMendonca CMacias LCavrel YAcosta MMadison MMurphy EColeman JMcMillan MGurung MSolomon VWindon CGrill JLaBarge RDeMarco ALieb BMcCann KTarawneh RKim CKataki MAggarwal RKim EMallory JHsiung RNath JDagerman KMcCurry CParry CVillinger TReichert CRaman RAlo TTam SChadwick MLu YWu PHerring SJennings LWisniewski SJimenez-Knight TKlemp HCline CBassett MVanya HAbusalim AEndre RChrestensen KLowe SRobert NLowe VMalloy PHo CSoto AO'Connell AMcDonnell MStephens SLong CGreig-Cust MPenn RWaszak JJessup ABritt KLong JNeugroschl JKormos AChirinos CRogers VLong RKing MRogers SKing KGroome AGillen LEsposito GTrncic NRogers JClayton VWilliamson JKing RSchultz OHsiao JKNguyen TTrojanowki JQHarp JReposa MNolan KNguyen MAl-Amin JNguyen LJimenez ALeader AJimenez GCampbell DRodzon BNatelson-Love MForloines MHorenkamp JfalseNeuropsychiatric symptoms in cognitive decline and Alzheimer's disease: biomarker discovery using plasma proteomics.<h4>Background and objectives</h4>Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.<h4>Methods</h4>A panel of 190 plasma proteins was quantified using Luminex xMAP in the Alzheimer's Disease Neuroimaging Initiative cohort. NPS and cognitive performance were assessed at baseline and after 1 and 2 years. Logistic regression, receiver operating characteristic analysis and cross-validation were used to address the relations of interest.<h4>Results</h4>A total of 507 participants with mild cognitive i2025-01-01T00:00:00Z2025 Mar2026-06-02T00:03:09.517Z2025-07-03T03:05:09.014ZS-EPMC120150823928896110.1136/jnnp-2024-333819