biostudies-literatureHe SUS CDC-Chinese Center for Disease Control and Prevention Cooperative AgreementMinistry of Public Health of the People’s Republic of ChinaNational Center for Cardiovascular Diseases &amp; Fuwai HospitalWorld BankDa Qing First HospitalUS CDC–Chinese Center for Disease Control and Prevention Cooperative AgreementUS Centers for Disease Control and Prevention (CDC)-WHO Cooperative AgreementChina-Japan Friendship HospitalChinese Academy of Medical Sciences, Innovation Fund for Medical Sciences24https://www.ebi.ac.uk/biostudies/studies/S-EPMC12015435biostudies-literatureUnknown3(1)<h4>Background</h4>We investigated the association between younger-onset type 2 diabetes, duration of diabetes, and cancer risk based on data from the Da Qing Diabetes Prevention Outcome Study (DQDPOS).<h4>Methods</h4>The analysis recruited 620 younger-onset (age≤50 years) and 649 older-onset (age>50 years) patients with type 2 diabetes, and 310 younger non-diabetes controls (age≤50 years). Multiple regression analysis was used to test the influence of younger-onset diabetes and duration of diabetes on the long-term risk of cancer.<h4>Results</h4>The annual incidence of all cancer among the non-diabetes, younger-, and older-onset type 2 diabetes was significantly different (3.7, 5.5, and 4.0/1000 person-years, respectively). The standard Cox analysis revealed that the patients with youngerBJC reportsYounger-onset type 2 diabetes associated with increased long-term cancer risk in Chinese adults: A 30-year follow-up of the Da Qing Diabetes Study.PMC12015435U58/CCU424123-01-022020-I2M-2-0065U19GH000636-05Li GLi HGong QWang JChen BQian XHe SJin CAn YChen YChen XWang YShen XZhang BfalseYounger-onset type 2 diabetes associated with increased long-term cancer risk in Chinese adults: A 30-year follow-up of the Da Qing Diabetes Study.<h4>Background</h4>We investigated the association between younger-onset type 2 diabetes, duration of diabetes, and cancer risk based on data from the Da Qing Diabetes Prevention Outcome Study (DQDPOS).<h4>Methods</h4>The analysis recruited 620 younger-onset (age≤50 years) and 649 older-onset (age>50 years) patients with type 2 diabetes, and 310 younger non-diabetes controls (age≤50 years). Multiple regression analysis was used to test the influence of younger-onset diabetes and duration of diabetes on the long-term risk of cancer.<h4>Results</h4>The annual incidence of all cancer among the non-diabetes, younger-, and older-onset type 2 diabetes was significantly different (3.7, 5.5, and 4.0/1000 person-years, respectively). The standard Cox analysis revealed that the patients with younger2025-01-01T00:00:00Z2025 Apr2025-07-01T03:04:59.503Z2025-07-01T03:04:59.503ZS-EPMC120154354026362810.1038/s44276-025-00142-5