{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao Z"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["3778"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12015548"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Microcapsules composed of synthetic polymeric matrices have attracted considerable attention in delivering oral probiotics. However, existing polymeric microcapsules demonstrate inadequate acid resistance and adaptability, as well as deficiency in the inflamed colon-specificity and uncontrolled release of probiotics therein. Herein, a DNA microcapsule is prepared as a probiotic-transporting micromotor through photo-crosslinking of hyaluronic acid methacrylate and acrydite-modified A-/C-rich oligomers within the microfludically generated droplets in the presence of nitric oxide-cleavable crosslinker and gas donor manganese carbonyl (MnCO). As the microcapsules traverse stomach, duodenum, and ultimately colon, the formation and dissociation of A-motif and i-motif structures instigate a rever"],"journal":["Nature communications"],"pubmed_title":["Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease."],"pmcid":["PMC12015548"],"funding_grant_id":["52373154"],"pubmed_authors":["Hu Y","Zhao Z","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease.","description":"Microcapsules composed of synthetic polymeric matrices have attracted considerable attention in delivering oral probiotics. However, existing polymeric microcapsules demonstrate inadequate acid resistance and adaptability, as well as deficiency in the inflamed colon-specificity and uncontrolled release of probiotics therein. Herein, a DNA microcapsule is prepared as a probiotic-transporting micromotor through photo-crosslinking of hyaluronic acid methacrylate and acrydite-modified A-/C-rich oligomers within the microfludically generated droplets in the presence of nitric oxide-cleavable crosslinker and gas donor manganese carbonyl (MnCO). As the microcapsules traverse stomach, duodenum, and ultimately colon, the formation and dissociation of A-motif and i-motif structures instigate a rever","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-01T03:05:03.002Z","creation":"2025-07-01T03:05:03.002Z"},"accession":"S-EPMC12015548","cross_references":{"pubmed":["40263286"],"doi":["10.1038/s41467-025-59172-9"]}}