{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dan U"],"funding":["University of Illinois System","National Institutes of Health","National Institute of General Medical Sciences","NIGMS NIH HHS","National Science Foundation"],"pagination":["105652"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12015550"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["166"],"pubmed_abstract":["Oxytocin (OXT) and its homologs are known to regulate parental care in vertebrates, but it is unknown what role these neuropeptides may play in the evolutionary loss of care. Here, we compared two recently diverged ecotypes of threespine stickleback (Gasterosteus aculeatus) that differ in parental care. Males of the common ecotype provide obligate, uniparental care to their offspring, whereas males of the white ecotype abandon their offspring after fertilization. To test if OXT plays a role in the loss of care, we manipulated OXT in males of both ecotypes via intraperitoneal injection of a vehicle control, OXT single- or double-dose, or an OXT antagonist. We observed the behavioral response to injection at two time points for commons (0 and 4 days post-fertilization (dpf)) and one for whit"],"journal":["Hormones and behavior"],"pubmed_title":["Oxytocin influences parental care in male threespine stickleback across multiple time scales."],"pmcid":["PMC12015550"],"funding_grant_id":["1R35GM139597","R35 GM139597"],"pubmed_authors":["Maciejewski MF","Bell AM","Schwaiger E","Dan U"],"additional_accession":[]},"is_claimable":false,"name":"Oxytocin influences parental care in male threespine stickleback across multiple time scales.","description":"Oxytocin (OXT) and its homologs are known to regulate parental care in vertebrates, but it is unknown what role these neuropeptides may play in the evolutionary loss of care. Here, we compared two recently diverged ecotypes of threespine stickleback (Gasterosteus aculeatus) that differ in parental care. Males of the common ecotype provide obligate, uniparental care to their offspring, whereas males of the white ecotype abandon their offspring after fertilization. To test if OXT plays a role in the loss of care, we manipulated OXT in males of both ecotypes via intraperitoneal injection of a vehicle control, OXT single- or double-dose, or an OXT antagonist. We observed the behavioral response to injection at two time points for commons (0 and 4 days post-fertilization (dpf)) and one for whit","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-07-07T03:10:03.868Z","creation":"2025-07-07T03:10:03.868Z"},"accession":"S-EPMC12015550","cross_references":{"pubmed":["39413541"],"doi":["10.1016/j.yhbeh.2024.105652"]}}