biostudies-literatureUnknown25(1)Giammarinaro E<h4>Background</h4>Improving soft tissue quality and quantity around dental implants is crucial for successful outcomes. Platelet-Rich Fibrin (PRF) is showing promise in enhancing wound healing and implant stability. This systematic review aims to evaluate the clinical benefits of PRF in soft tissue regeneration around dental implants compared to standard methods.<h4>Methods</h4>This systematic review adhered to the PRISMA guidelines and utilizing the PICO methodology, investigated the use of Platelet-Rich Fibrin (PRF) in soft tissue augmentation during implant therapy. The primary outcomes assessed include the width of keratinized mucosa and soft tissue thickness, comparing PRF interventions to standard techniques.The study included randomized controlled trials (RCTs) and comparative studBMC oral health615https://www.ebi.ac.uk/biostudies/studies/S-EPMC12016366biostudies-literatureDoes platelet-rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review.PMC12016366Marconcini SGiammarinaro EMenini MBaldini NCovani UPesce PfalseDoes platelet-rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review.<h4>Background</h4>Improving soft tissue quality and quantity around dental implants is crucial for successful outcomes. Platelet-Rich Fibrin (PRF) is showing promise in enhancing wound healing and implant stability. This systematic review aims to evaluate the clinical benefits of PRF in soft tissue regeneration around dental implants compared to standard methods.<h4>Methods</h4>This systematic review adhered to the PRISMA guidelines and utilizing the PICO methodology, investigated the use of Platelet-Rich Fibrin (PRF) in soft tissue augmentation during implant therapy. The primary outcomes assessed include the width of keratinized mucosa and soft tissue thickness, comparing PRF interventions to standard techniques.The study included randomized controlled trials (RCTs) and comparative stud2025-01-01T00:00:00Z2025 Apr2025-07-02T03:05:07.641Z2025-07-02T03:05:07.641ZS-EPMC120163664026408110.1186/s12903-025-05922-6