biostudies-literatureKoh JMinistry of Health and Welfare443-456https://www.ebi.ac.uk/biostudies/studies/S-EPMC12016828biostudies-literatureUnknown57(2)<h4>Purpose</h4>Considering the high disease burden and unique features of Asian patients with breast cancer (BC), it is essential to have a comprehensive view of genetic characteristics in this population. An institutional targeted sequencing platform was developed through the Korea Research-Driven Hospitals project and was incorporated into clinical practice. This study explores the use of targeted next-generation sequencing (NGS) and its outcomes in patients with advanced/metastatic BC in the real world.<h4>Materials and methods</h4>We reviewed the results of NGS tests administered to BC patients using a customized sequencing platform-FiRST Cancer Panel (FCP)-over 7 years. We systematically described clinical translation of FCP for precise diagnostics, personalized therapeutic strategieCancer research and treatmentHarnessing Institutionally Developed Clinical Targeted Sequencing to Improve Patient Survival in Breast Cancer: A Seven-Year Experience.PMC12016828HR14C0003Lee SKim TYKim JISeo JYun HKwon SYSong MGLee DWSeong MWKim JChoi JJeon YKKim MWon JKLee JSKim SRyu HSYi HWoo GUBae JMKoh JKim JHIm SALee KHfalseHarnessing Institutionally Developed Clinical Targeted Sequencing to Improve Patient Survival in Breast Cancer: A Seven-Year Experience.<h4>Purpose</h4>Considering the high disease burden and unique features of Asian patients with breast cancer (BC), it is essential to have a comprehensive view of genetic characteristics in this population. An institutional targeted sequencing platform was developed through the Korea Research-Driven Hospitals project and was incorporated into clinical practice. This study explores the use of targeted next-generation sequencing (NGS) and its outcomes in patients with advanced/metastatic BC in the real world.<h4>Materials and methods</h4>We reviewed the results of NGS tests administered to BC patients using a customized sequencing platform-FiRST Cancer Panel (FCP)-over 7 years. We systematically described clinical translation of FCP for precise diagnostics, personalized therapeutic strategie2025-01-01T00:00:00Z2025 Apr2025-07-02T03:04:59.876Z2025-07-02T03:04:59.876ZS-EPMC120168283916408210.4143/crt.2024.296