{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arvind V"],"funding":["NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["eadn5409"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12017337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(17)"],"pubmed_abstract":["Tendon injuries heal by scar, leading to poor function. To date, the role of immune cells remains underexplored. Using a neonatal mouse model of functional tendon healing compared to adult scar-mediated healing, we identified a regenerative immune profile that is associated with type 1 inflammation followed by rapid polarization to type 2, driven by macrophages and regulatory T cells (T<sub>reg</sub> cells). Single-cell and bulk RNA sequencing also revealed neonatal T<sub>reg</sub> cells with an immunomodulatory signature distinct from adult. Neonatal T<sub>reg</sub> cell ablation resulted in a dysregulated immune response, failed tenocyte recruitment, and impaired regeneration. Adoptive transfer further confirmed the unique capacity of neonatal T<sub>reg</sub> cells to rescue functional r"],"journal":["Science advances"],"pubmed_title":["Functional tendon regeneration is driven by regulatory T cells and IL-33 signaling."],"pmcid":["PMC12017337"],"funding_grant_id":["R56 AR076984","R01 AR069537","R01 AR081674","F31 AR076905","T32 GM007280"],"pubmed_authors":["Crosio G","Zhang H","Montero A","Arvind V","Howell K","Huang AH"],"additional_accession":[]},"is_claimable":false,"name":"Functional tendon regeneration is driven by regulatory T cells and IL-33 signaling.","description":"Tendon injuries heal by scar, leading to poor function. To date, the role of immune cells remains underexplored. Using a neonatal mouse model of functional tendon healing compared to adult scar-mediated healing, we identified a regenerative immune profile that is associated with type 1 inflammation followed by rapid polarization to type 2, driven by macrophages and regulatory T cells (T<sub>reg</sub> cells). Single-cell and bulk RNA sequencing also revealed neonatal T<sub>reg</sub> cells with an immunomodulatory signature distinct from adult. Neonatal T<sub>reg</sub> cell ablation resulted in a dysregulated immune response, failed tenocyte recruitment, and impaired regeneration. Adoptive transfer further confirmed the unique capacity of neonatal T<sub>reg</sub> cells to rescue functional r","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-02T04:13:08.803Z","creation":"2025-07-06T03:04:32.012Z"},"accession":"S-EPMC12017337","cross_references":{"pubmed":["40267206"],"doi":["10.1126/sciadv.adn5409"]}}