{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hacker D"],"funding":["Leona M and Harry B Helmsley Charitable Trust","Deutsche Forschungsgemeinschaft","NHLBI NIH HHS","National Research Foundation Singapore","Ludwig-Maximilians-Universität München"],"pagination":["2019-2034.e8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12017801"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(11)"],"pubmed_abstract":["Exclusive enteral nutrition (EEN) is a first-line therapy for pediatric Crohn's disease (CD), but protective mechanisms remain unknown. We established a prospective pediatric cohort to characterize the function of fecal microbiota and metabolite changes of treatment-naive CD patients in response to EEN (German Clinical Trials DRKS00013306). Integrated multi-omics analysis identified network clusters from individually variable microbiome profiles, with Lachnospiraceae and medium-chain fatty acids as protective features. Bioorthogonal non-canonical amino acid tagging selectively identified bacterial species in response to medium-chain fatty acids. Metagenomic analysis identified high strain-level dynamics in response to EEN. Functional changes in diet-exposed fecal microbiota were further va"],"journal":["Cell host & microbe"],"pubmed_title":["Exclusive enteral nutrition initiates individual protective microbiome changes to induce remission in pediatric Crohn's disease."],"pmcid":["PMC12017801"],"funding_grant_id":["SFB 1371","R01 HL160862","2304-05970","395357507","2847"],"pubmed_authors":["Heetmeyer J","Hacker D","Kohler N","Kleigrewe K","List M","Nie J","Smith BJ","Metwaly A","Pollard KS","Schwerd T","De Zen F","Riva A","Le Thi G","Neuhaus K","Heimes H","Holz H","Pauling JK","Mahapatra A","Meng C","Socas K","Haller D","Manz Q","Siebert K"],"additional_accession":[]},"is_claimable":false,"name":"Exclusive enteral nutrition initiates individual protective microbiome changes to induce remission in pediatric Crohn's disease.","description":"Exclusive enteral nutrition (EEN) is a first-line therapy for pediatric Crohn's disease (CD), but protective mechanisms remain unknown. We established a prospective pediatric cohort to characterize the function of fecal microbiota and metabolite changes of treatment-naive CD patients in response to EEN (German Clinical Trials DRKS00013306). Integrated multi-omics analysis identified network clusters from individually variable microbiome profiles, with Lachnospiraceae and medium-chain fatty acids as protective features. Bioorthogonal non-canonical amino acid tagging selectively identified bacterial species in response to medium-chain fatty acids. Metagenomic analysis identified high strain-level dynamics in response to EEN. Functional changes in diet-exposed fecal microbiota were further va","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-07-02T03:04:55.769Z","creation":"2025-07-02T03:04:55.769Z"},"accession":"S-EPMC12017801","cross_references":{"pubmed":["39461337"],"doi":["10.1016/j.chom.2024.10.001"]}}