{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Tanabe H"],"funding":["Fujifilm Corporation","Japan Agency for Medical Research and Development","Japan Society for the Promotion of Science"],"pubmed_abstract":["Abnormal accumulation of tau proteins in the brain is a hallmark of neurodegenerative diseases such as Alzheimer's disease and is closely linked with neuronal cell death. Tau accumulation is a prominent therapeutic target for Alzheimer's disease, since tau accumulation correlates well with the disease progression, and tau-targeting drugs hold potentials to halt the disease progression. Given the differential response of human and mouse neuronal cells, there is a critical need for a human cellular platform to quickly screen for tau-related neurodegenerative disease therapeutics. However, inducing rapid, tau-dependent neuronal cell death in human models remains challenging. In this study, we established a human cellular model capable of inducing tau aggregation-dependent neuronal cell death "],"journal":["Aging brain"],"pagination":["100136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12018045"],"repository":["biostudies-literature"],"pubmed_title":["Tau aggregation induces cell death in iPSC-derived neurons."],"pmcid":["PMC12018045"],"pubmed_authors":["Tanabe H","Okano H","Maeda S","Endoh-Yamagami S","Sano E","Sakai N"],"additional_accession":[]},"is_claimable":false,"name":"Tau aggregation induces cell death in iPSC-derived neurons.","description":"Abnormal accumulation of tau proteins in the brain is a hallmark of neurodegenerative diseases such as Alzheimer's disease and is closely linked with neuronal cell death. Tau accumulation is a prominent therapeutic target for Alzheimer's disease, since tau accumulation correlates well with the disease progression, and tau-targeting drugs hold potentials to halt the disease progression. Given the differential response of human and mouse neuronal cells, there is a critical need for a human cellular platform to quickly screen for tau-related neurodegenerative disease therapeutics. However, inducing rapid, tau-dependent neuronal cell death in human models remains challenging. In this study, we established a human cellular model capable of inducing tau aggregation-dependent neuronal cell death ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-02T18:25:17.829Z","creation":"2026-04-18T03:14:00.067Z"},"accession":"S-EPMC12018045","cross_references":{"pubmed":["40276591"],"doi":["10.1016/j.nbas.2025.100136"]}}