biostudies-literatureUnknown7Tanabe HFujifilm CorporationJapan Agency for Medical Research and DevelopmentJapan Society for the Promotion of ScienceAbnormal accumulation of tau proteins in the brain is a hallmark of neurodegenerative diseases such as Alzheimer's disease and is closely linked with neuronal cell death. Tau accumulation is a prominent therapeutic target for Alzheimer's disease, since tau accumulation correlates well with the disease progression, and tau-targeting drugs hold potentials to halt the disease progression. Given the differential response of human and mouse neuronal cells, there is a critical need for a human cellular platform to quickly screen for tau-related neurodegenerative disease therapeutics. However, inducing rapid, tau-dependent neuronal cell death in human models remains challenging. In this study, we established a human cellular model capable of inducing tau aggregation-dependent neuronal cell death Aging brain100136https://www.ebi.ac.uk/biostudies/studies/S-EPMC12018045biostudies-literatureTau aggregation induces cell death in iPSC-derived neurons.PMC12018045Tanabe HOkano HMaeda SEndoh-Yamagami SSano ESakai NfalseTau aggregation induces cell death in iPSC-derived neurons.Abnormal accumulation of tau proteins in the brain is a hallmark of neurodegenerative diseases such as Alzheimer's disease and is closely linked with neuronal cell death. Tau accumulation is a prominent therapeutic target for Alzheimer's disease, since tau accumulation correlates well with the disease progression, and tau-targeting drugs hold potentials to halt the disease progression. Given the differential response of human and mouse neuronal cells, there is a critical need for a human cellular platform to quickly screen for tau-related neurodegenerative disease therapeutics. However, inducing rapid, tau-dependent neuronal cell death in human models remains challenging. In this study, we established a human cellular model capable of inducing tau aggregation-dependent neuronal cell death 2025-01-01T00:00:00Z20252026-06-02T18:25:17.829Z2026-04-18T03:14:00.067ZS-EPMC120180454027659110.1016/j.nbas.2025.100136